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Numéro de catalogue:
(PRSI26-242)
Fournisseur:
ProSci Inc.
Description:
ZNF131 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 1 BTB (POZ) domain and 6 C2H2-type zinc fingers. It may be involved in transcriptional regulation. ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6801P)
Fournisseur:
ProSci Inc.
Description:
TFEB peptide is used for blocking the activity of TFEB antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-531)
Fournisseur:
ProSci Inc.
Description:
Part of the connexin genes, the CX40.1 gene appears to have evolved to different expression patterns and presumably to different functions compared to its orthologue in the mouse genome.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-549)
Fournisseur:
ProSci Inc.
Description:
The RUNX2 gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-540)
Fournisseur:
ProSci Inc.
Description:
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3589P)
Fournisseur:
ProSci Inc.
Description:
Precerebellin peptide is used for blocking the activity of Precerebellin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI35-280)
Fournisseur:
ProSci Inc.
Description:
Anti-Influenza Goat Polyclonal Antibody (Biotin)
UOM:
1 * 1 mL
Numéro de catalogue:
(PRSI3569P)
Fournisseur:
ProSci Inc.
Description:
CTRP4 peptide is used for blocking the activity of CTRP4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-545)
Fournisseur:
ProSci Inc.
Description:
MCM8 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-452)
Fournisseur:
ProSci Inc.
Description:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-451)
Fournisseur:
ProSci Inc.
Description:
PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-448)
Fournisseur:
ProSci Inc.
Description:
p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-472)
Fournisseur:
ProSci Inc.
Description:
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-439)
Fournisseur:
ProSci Inc.
Description:
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6925P)
Fournisseur:
ProSci Inc.
Description:
APBA1 peptide is used for blocking the activity of APBA1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-310)
Fournisseur:
ProSci Inc.
Description:
WDR34 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
UOM:
1 * 50 µG
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