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ProSci Inc.
Numéro de catalogue:
(PRSI14-086)
Fournisseur:
ProSci Inc.
Description:
Anti-OTUB1 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
New Product
Numéro de catalogue:
(PRSI14-126)
Fournisseur:
ProSci Inc.
Description:
Anti-NQO2 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
New Product
Numéro de catalogue:
(PRSI14-106)
Fournisseur:
ProSci Inc.
Description:
Anti-SLC6A11 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
New Product
Numéro de catalogue:
(PRSI14-129)
Fournisseur:
ProSci Inc.
Description:
Anti-STUB1 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
New Product
Numéro de catalogue:
(PRSI14-112)
Fournisseur:
ProSci Inc.
Description:
Anti-PPP5C Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
New Product
Numéro de catalogue:
(PRSI14-135)
Fournisseur:
ProSci Inc.
Description:
Anti-KCNE1 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
New Product
Numéro de catalogue:
(PRSI76-068)
Fournisseur:
ProSci Inc.
Description:
The 5E10 monoclonal antibody specifically reacts with human CD90, also known as thymus cell antigen-1 (Thy-1). CD90 is a 25 to 37 kDa GPI-anchored protein is the smallest member of the Ig superfamily. CD90 is expressed on thymocytes, neurons, mesenchymal stem cells, hematopoietic stem cells, NK cells, and follicular dendritic cells and plays a role in inflammation, metastasis, apoptosis, and nerve regeneration. The 5E10 antibody can be used for the enriching high proliferative potential colony-forming cells (HIPP-CFC).
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI76-088)
Fournisseur:
ProSci Inc.
Description:
The ICRF44 monoclonal antibody specifically reacts with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin beta 2) a complex known as Mac-1. CD11b is expressed on the surface of activated lymphocytes, a subset of natural killer cells, granulocytes, and monocytes. It functions as a receptor in cell-cell and cell-matrix interactions and as a receptor for iC3b, ICAM-1, ICAM-2, and ICAM-3 intercellular adhesion molecules.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-465)
Fournisseur:
ProSci Inc.
Description:
It recognises a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-456)
Fournisseur:
ProSci Inc.
Description:
UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-419)
Fournisseur:
ProSci Inc.
Description:
Recognises a protein of 110 kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This mAb is superb for staining of formalin/paraffin tissues.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-434)
Fournisseur:
ProSci Inc.
Description:
Recognises a protein of 40 kDa, identified as cytokeratin-19 (CK19), which is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-418)
Fournisseur:
ProSci Inc.
Description:
Recognises a protein of 110 kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This mAb is superb for staining of formalin/paraffin tissues.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-462)
Fournisseur:
ProSci Inc.
Description:
This mAb stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffer's cells of the liver and Langerhan's cells of the skin. It also stains the mantle zone B-lymphocytes of the lymph node and spleen, spermatogonia, and chief cells of the stomach. S100A9 is expressed by macrophages in acutely inflamed tissues and in chronic inflammation. It is detected in peripheral blood leukocytes, in neutrophils and granulocytes. It is present at sites of vascular inflammation. S100A9 is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a Calcium-binding protein. It has antimicrobial activity towards bacteria and fungi. It is important for resistance to invasion by pathogenic bacteria. It up-regulates transcription of genes that are under the control of NF-kappa-B. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. It plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-452)
Fournisseur:
ProSci Inc.
Description:
Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterised by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognises target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI55-503)
Fournisseur:
ProSci Inc.
Description:
For WB starting dilution is: 1:1000
UOM:
1 * 400 µl
New Product
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Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'
est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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