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STEMCELL Technologies
Fournisseur:
STEMCELL Technologies
Description:
Flt3/Flk-2 (Fms-like tyrosine kinase 3/fetal liver kinase-2) Ligand is a hematopoietic cytokine that plays an important role as a co-stimulatory factor in the proliferation, differentiation, and survival of hematopoietic stem and progenitor cells and the development of the immune system (Hannum <i>et al.</i>). Flt3/Flk-2 Ligand, together with stem cell factor and thrombopoietin, is commonly used to promote expansion of primitive CD34+ hematopoietic cells in culture. In combination with myeloid cytokines such as GM-CSF, G-CSF, or M-CSF, Flt3/Flk-2 Ligand enhances the growth and numbers of clonogenic myeloid progenitor cells. In synergy with the interleukins IL-3, IL-4, IL-7, IL-11, IL-12, IL-15, and GM-CSF and TNF-α, Flt3/Flk-2 Ligand regulates the development of various lymphoid progenitor cells, including dendritic cell, B cell, T cell, and NK cell progenitors. In contrast, Flt3/Flk-2 Ligand has no significant effect on erythropoiesis or megakaryopoiesis (Drexler and Quentmeier; Wodnar-Filipowicz). Flt3/Flk-2 Ligand exists as membrane-bound and soluble isoforms. Both isoforms are biologically active and signal through the class III tyrosine kinase receptor (Flt3/Flk-2, CD135; Rosnet <i>et al.</i>). Flt3/Flk-2 Ligand is produced by a variety of cell types, including uncommitted and committed hematopoietic cells and stromal fibroblasts, whereas expression of the Flt3/Flk-2 receptor is restricted to CD34+ hematopoietic stem and progenitor cells. Flt3/Flk-2 receptor is also expressed on leukemic cells and outside the hematopoietic system in the brain, placenta, and testis (Drexler and Quentmeier; Hannum <i>et al.</i>). This product is animal component-free.
Fournisseur:
STEMCELL Technologies
Description:
Growth differentiation factor 11 (GDF-11) is a member of transforming growth factor beta (TGF-β) family. It binds to the TGF-β receptors ALK4, ALK5, and ALK7 and activates the SMAD signaling pathway (Ho <i>et al.</i>). GDF-11 regulates the development of the olfactory system, retina, and pancreas, as well as anterior/posterior patterning of the axial skeleton (Lee and Lee). GDF-11 is an endocrine factor expressed in skeletal muscle, brain, and dental pulp (Kondás <i>et al.</i>). Studies in mice showed that GDF-11 regulates muscle and cardiac aging, and stimulates neurogenesis by remodeling blood vessels (Katsimpardi <i>et al.</i>; Loffredo <i>et al.</i>; Sinha <i>et al.</i>). This product is animal component-free.
Fournisseur:
STEMCELL Technologies
Description:
Brain-derived neurotrophic factor (BDNF), like nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), is a member of the NGF family of neurotrophins, which are required for the differentiation and survival of specific neuronal subpopulations in both the central and the peripheral nervous systems (Minichiello and Klein; Minichiello <i>et al.</i>). BDNF binds with high affinity to the TRKB kinase receptor, and activates AKT and ERK pathways (Mattson <i>et al.</i>). It is expressed in hippocampus, cortex, and synapses of the basal forebrain. BDNF acts as a survival factor for human embryonic stem cells when plated on either feeder cells or Corning® Matrigel® (Pyle <i>et al.</i>). BDNF regulates synaptic transmission and plasticity at adult synapses in the central nervous system, contributes to adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, as well as homeostatic regulation of neuronal excitability (Reichardt). It also has a role in neurogenesis by promoting survival and growth of dorsal root ganglion cells, and hippocampal and cortical neurons (Binder and Scharfman). BDNF, together with glial cell-derived neurotrophic factor (GDNF) and other supplements, is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Brafman). This product is animal component-free.
Numéro de catalogue:
(STMC100-0401)
Fournisseur:
STEMCELL Technologies
Description:
Animal origin-free, stabilized, feeder-free maintenance medium for human ES and iPS cells.
UOM:
1 * 1 Kit
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
A cellular protein for detection of apoptotic cells, FITC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic isolation of mouse CD4+CD25+ regulatory T cells.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic positive selection of human CD19+ cells (e.g. B cells).
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1, kappa isotype control antibody, biotin-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Animal component-free collagenase for the digestion of native collagen fibrils.
Fournisseur:
STEMCELL Technologies
Description:
For digestion of native collagen fibrils.
Numéro de catalogue:
(STMC18002)
Fournisseur:
STEMCELL Technologies
Description:
The EasySep™ Easy 50 magnet is designed for cell separation procedures using selected EasySep™ reagents when processing a large number of cells (up to 4×10⁹ cells).
UOM:
1 * 1 KIT
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Numéro de catalogue:
(STMC04035)
Fournisseur:
STEMCELL Technologies
Description:
Methylcellulose-based medium with recombinant cytokines (without EPO) for human cells. 1×100 ml bottle.
UOM:
1 * 100 mL
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Numéro de catalogue:
(STMC60144)
Fournisseur:
STEMCELL Technologies
Description:
Rabbit polyclonal antibody against human, mouse SHIP, unconjugated.
UOM:
1 * 100 µl
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Numéro de catalogue:
(STMC04044)
Fournisseur:
STEMCELL Technologies
Description:
Pre-aliquoted methylcellulose-based medium with recombinant cytokines for human cells. 24×3ml vials.
UOM:
1 * 24 ST
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgM antibody against human, rhesus, rabbit TRA160 (podocalyxin), PE-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human CD56 (NCAM), APCconjugated.
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