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STEMCELL Technologies
Numéro de catalogue:
(STMC100-1399)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with JCV (LT) Peptide Pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This peptide pool is a lyophilised mixture of 170 peptides from large T antigen (LT) of JC polyomavirus (JCV), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 688 on LT. LT is detectable during JCV latency (Rossi <i>et al.</i>), and in immunocompromised patients with JVC-associated pathologies such as progressive multifocal leukoencephalopathy (PML) (Delbue <i>et al.</i>). In PML, LT has been associated with activating the promoter of survivin, an anti-apoptotic protein (Del Valle <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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Fournisseur:
STEMCELL Technologies
Description:
Stromal cell-derived factor 1 alpha (SDF-1α) is a member of the CXC group of chemokines that binds to the G-protein coupled receptor, CXCR4, to regulate migration, proliferation, differentiation, and survival of many cell types including hematopoietic stem cells, B cells, and T cells. It is produced by bone marrow stromal cells, osteoblasts, endothelial cells, and neuronal cells. SDF-1α was first identified as the pre-B-cell growth-stimulating factor (PBSF) in the mouse bone marrow-derived stromal cell line, PA6, in the growth of B cell precursors (Hayashi <i>et al.</i>). SDF-1α primarily regulates cell motility during development and adulthood, including the homing of hematopoietic stem cells and neutrophils to fetal bone marrow during ontogeny (Ara <i>et al.</i> 2003a) and the recruitment of endothelial progenitor cells from bone marrow during angiogenesis in adulthood (Zheng <i>et al.</i>). In addition to its role in hematopoiesis, the SDF-1α/CXCR4 signaling pathway is also essential for the homing of primordial germ cells to gonads (Ara <i>et al.</i> 2003b), the migration of granule cells in the cerebellum during neurogenesis (Zou <i>et al.</i>), and the migration of breast cancer cells to sites of metastasis (Muller <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 16 (FGF-16) is a heparin-binding member of the FGF family. FGFs possess broad mitogenic and cell survival activities and are expressed during embryonic development. FGFs act primarily on cells of mesodermal and neuroectodermal origin to regulate diverse physiological functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, and tissue repair (Goldfarb; Green <i>et al.</i>). In vitro, FGF-16 has been shown to promote the proliferation of brown adipocytes and in rat embryos it is predominantly expressed in these cells. FGF-16 has also been shown to play a critical role in embryonic heart development and is thought to play a cardioprotective role after birth (Hotta <i>et al.</i>; Lu <i>et al.</i>; Wang <i>et al.</i>).
Numéro de catalogue:
(STMC100-1598)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal antibody against mouse CD45.2, APC-conjugated.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1346)
Fournisseur:
STEMCELL Technologies
Description:
Rabbit polyclonal antibody against human SATB2 (GLSS).
UOM:
1 * 200 µl
New Product
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Numéro de catalogue:
(STMC100-1460)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal antibody against human IFN-gamma, unconjugated.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1403)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with HHV8 (K8) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HHV8 (K8) peptide pool is a lyophilised mixture of 57 peptides from protein K8 alpha of human herpesvirus 8 (HHV-8), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 237 on K8. A basic leucine zipper (bZip) protein that associates with the lytic origin of HHV8 (Lin <i>et al.</i>), K8 is thought to play a role in lytic DNA replication, as a trans-acting factor (AuCoin <i>et al.</i>). It has also been found to modulate the activity of the transcriptional transactivator K-Rta (Izumiya <i>et al.</i>), and has an autoregulatory function (Wang <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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Fournisseur:
STEMCELL Technologies
Description:
Vascular endothelial growth factor (VEGF-121) is a naturally-occurring VEGF-A splice variant involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 and VEGFR-2, and activates Raf/MEK/ERK and PI3K/AKT pathways. VEGF-121 is released as a freely diffusible protein by a variety of normal and transformed cells. It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum <i>et al.</i>). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
GRO (growth-regulated oncogene)-beta or CXCL2 is a member of the CXC family, which plays an integral role in recruitment and activation of neutrophils and basophils in response to tissue injury and microbial infection. GRO-beta and GRO-gamma are closely related to GRO-alpha and share 90% and 86% amino acid sequence homology, respectively, with GRO-alpha. Receptor-binding studies have demonstrated that GRO-alpha, -beta, and -gamma signal mainly through G protein-coupled receptors CXCR1 and CXCR2 (Ahuja and Murphy). GRO-beta is expressed in epithelial cells, monocytes, fibroblasts, and melanocytes and is further induced during inflammatory, epithelialization, and angiogenic processes, for example during the wound healing process of human burn wounds (Zaja-Milatovic and Richmond). GRO-beta also stimulates mitogenesis in certain human melanoma cells (Unemori <i>et al.</i>).
Numéro de catalogue:
(STMC100-1407)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with Candida (MP65) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. Candida peptide pool is a lyophilised mixture of 92 peptides from the mannoprotein MP65 of Candida albicans (yeast), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 379 on MP65. MP65 contributes to cell wall integrity and epithelia adherence (Sandini <i>et al.</i>), and is a potent T cell immunogen (Gomez <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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Numéro de catalogue:
(STMC100-1454)
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal antibody against human IL-4, unconjugated.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1465)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal antibody against human, cynomolgus IL-2.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1130)
Fournisseur:
STEMCELL Technologies
Description:
cGMP, stabilised feeder-free maintenance medium for human ES and iPS cells.
UOM:
1 * 1 L
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Numéro de catalogue:
(STMC100-1459)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal antibody against human IFN-gamma, FITC-conjugated.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1326)
Fournisseur:
STEMCELL Technologies
Description:
Commonly known as vaspin, Serpin A12 is an adipokine that is thought to perform insulin-sensitizing functions, such as the regulation of kallikrein 7 (KLK7), an insulin-inhibiting protease (Heiker <i>et al.</i>). The Serpin A12 glycoprotein belongs to the serine protease inhibitor family (serpin), and is mainly associated with obesity, insulin resistance, and glucose metabolism, but may also protect against high fat-induced bone loss (Wang <i>et al.</i>). Serpins share a highly conserved core structure with multiple α-helices, β-strands, and a reactive site loop (RCL) to interact with the target protease (Huntington). It is expressed predominantly in visceral adipose tissue and at significantly higher amounts in obese individuals (Kurowska <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, Serpin A12 from STEMCELL comes lyophilised with ≥94% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1388)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with EBV (LMP1) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. EBV (LMP1) Peptide pool is a lyophilised mixture of 94 peptides from latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV; strain B95-8), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 386 on LMP1. LMP1 is essential for EBV-mediated growth transformation of B cells (Kaye <i>et al.</i>) and has been shown to downregulate toll-like receptor 9 (TLR9) expression in infected cells, a mechanism the virus may use to escape host innate immune recognition (Fathallah <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
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