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STEMCELL Technologies
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal IgG antibody against mouse CD11c, biotin-conjugated.
Numéro de catalogue:
(STMC60147)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human epithelial cells, unconjugated.
UOM:
1 * 0,1 mL
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 18 (FGF-18) is a growth factor and member of the FGF subfamily. FGF-18 is most similar to FGF-8 and FGF-17, and is secreted in adult lung and developing tissues (Ohbayashi <i>et al.</i>). FGF-18 signals through FGF receptor 3 (FGFR3) to regulate proliferation, differentiation, and matrix production of articular and growth plate chondrocytes <i>in vivo</i> and in vitro (Davidson <i>et al.</i>). FGF-18 has skeletal functions and protects articular cartilage by gene expression profiling and regulates proliferation and differentiation of midline cerebellar structures (Mori <i>et al.</i>). Also, recombinant human FGF-18 has been shown to effectively regulate hair growth (Song <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG2a antibody against mouse, toad CD8a, FITC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal IgG antibody against mouse CD11c, FITC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic isolation of untouched human CD4+ T cells.
Numéro de catalogue:
(STMC84544)
Fournisseur:
STEMCELL Technologies
Description:
Methylcellulose-based medium with recombinant cytokines (without EPO). 24×3 ml vials.
UOM:
1 * 24 VIA
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Numéro de catalogue:
(STMC60108)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG2a, kappa isotype control antibody, unconjugated.
UOM:
1 * 1 EA
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Fournisseur:
STEMCELL Technologies
Description:
Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld <i>et al.</i>). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops and Renauld; Fontaine <i>et al.</i>). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh <i>et al.</i>; Goswami and Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine <i>et al.</i>). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan <i>et al.</i>).
Numéro de catalogue:
(STMC60108FI)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG2a, kappa isotype control antibody, FITC-conjugated.
UOM:
1 * 1 EA
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Fournisseur:
STEMCELL Technologies
Description:
Brain-derived neurotrophic factor (BDNF), like nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), is a member of the NGF family of neurotrophins, which are required for the differentiation and survival of specific neuronal subpopulations in both the central and the peripheral nervous systems (Minichiello and Klein; Minichiello <i>et al.</i>). BDNF binds with high affinity to the tropomyosin receptor kinase B (TrkB), and activates AKT and ERK pathways (Mattson <i>et al.</i>). It is expressed in the hippocampus, cortex, and synapses of the basal forebrain. BDNF acts as a survival factor for human embryonic stem cells when plated on either feeder cells or Corning® Matrigel® (Pyle <i>et al.</i>). BDNF regulates synaptic transmission and plasticity at adult synapses in the central nervous system, and contributes to adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, and homeostatic regulation of neuronal excitability (Reichardt). It also has a role in neurogenesis by promoting survival and growth of dorsal root ganglion cells, and hippocampal and cortical neurons (Binder and Scharfman). BDNF, together with glial cell line-derived neurotrophic factor (GDNF) and other supplements, is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Brafman).
Numéro de catalogue:
(STMC60038PE)
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG2b antibody against mouse EPCR (CD201), PE-conjugated.
UOM:
1 * 0,5 mL
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Fournisseur:
STEMCELL Technologies
Description:
Epidermal growth factor (EGF) is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright <i>et al.</i>). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds and Weiss).
Fournisseur:
STEMCELL Technologies
Description:
Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>).
Numéro de catalogue:
(STMC03801)
Fournisseur:
STEMCELL Technologies
Description:
Myeloma and hybridoma culture medium (serum-containing).
UOM:
1 * 500 mL
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Numéro de catalogue:
(STMC05402)
Fournisseur:
STEMCELL Technologies
Description:
Supplement for detection of CFU-F and expansion of human mesenchymal stem cells.
UOM:
1 * 50 mL
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