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STEMCELL Technologies
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgM, kappa isotype control antibody, biotin-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against mouse, rat, guinea pig CD90/CD90.1, PE-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal IgG1 antibody against mouse CD3e, PE-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human CD34, APC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human, mouse CD105 (endoglin), Alexa Fluor® 488-conjugated.
Numéro de catalogue:
(STMC04100)
Fournisseur:
STEMCELL Technologies
Description:
Base methylcellulose medium for human cells.
UOM:
1 * 40 mL
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Numéro de catalogue:
(STMC05916)
Fournisseur:
STEMCELL Technologies
Description:
Defined, serum-free, xeno-free medium for pluripotent stem cells.
UOM:
1 * 1 KIT
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Numéro de catalogue:
(STMC07151)
Fournisseur:
STEMCELL Technologies
Description:
For neural and pancreatic differentiation of mouse ES and iPS cells.
UOM:
1 * 5 mL
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Numéro de catalogue:
(STMC10977)
Fournisseur:
STEMCELL Technologies
Description:
Culture supplement for the differentiation of human naïve CD4+ T cells into tregs.
UOM:
1 * 1 mL
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Fournisseur:
STEMCELL Technologies
Description:
Stem cell factor (SCF) is an early-acting cytokine that plays a pivotal role in the regulation of embryonic and adult hematopoiesis. SCF promotes cell survival, proliferation, differentiation, adhesion, and functional activation of cells at multiple levels of the hematopoietic hierarchy. Together with other cytokines such as thrombopoietin and Flt3/Flk-2 Ligand, SCF is commonly used to promote expansion of primitive hematopoietic stem cells and multi-potent progenitor cells in culture (Martin <i>et al.</i>; Kent <i>et al.</i>). In synergy with various growth factors, including IL-2, IL-3, IL-6, IL-7, G-CSF, and erythropoietin, SCF increases proliferation and differentiation of myeloid and erythroid progenitor cells and a subset of lymphoid progenitor cells (Broudy). SCF is also a primary growth and activation factor for mast cells and eosinophils. SCF exists in two biologically active splice forms: a soluble and a transmembrane isoform. Upon binding to its receptor (c-Kit tyrosine kinase receptor; CD117), it activates PI3K, JAK/STAT, and MAPK pathways. SCF and signaling from c-Kit have also been reported to play an important role in pigmentation, fertility, vasculogenesis, motility of the gut via c-Kit positive interstitial cells of Cajal, and in the migration of neuronal stem and progenitor cells to sites of injury in the brain.
Fournisseur:
STEMCELL Technologies
Description:
Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitor cells (Barreda <i>et al.</i>). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 cells T cells (Francisco-Cruz <i>et al.</i>). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton <i>et al.</i>). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz <i>et al.</i>). Recombinant rat GM-CSF is reactive with mouse cells (Oaks <i>et al.</i>; Vandenabeele <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 6 (IL-6) is a pleiotropic growth factor with a wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Nordan <i>et al.</i>; Van Snick <i>et al.</i>; Gauldie <i>et al.</i>; Mihara <i>et al.</i>; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF, and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of the JAK/STAT signaling pathway (Mihara <i>et al.</i>; Peters et al; Tanaka <i>et al.</i>).
Numéro de catalogue:
(STMC03815)
Fournisseur:
STEMCELL Technologies
Description:
Chemically defined, animal component-free, serum-free, protein-free, glutamine-free semi-solid methylcellulose-based medium for selection and cloning of CHO cells.
UOM:
1 * 90 mL
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Numéro de catalogue:
(STMC03810)
Fournisseur:
STEMCELL Technologies
Description:
Semi-solid methylcellulose-based hybridoma selection and cloning medium without HAT (serum-containing).
UOM:
1 * 90 mL
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Numéro de catalogue:
(STMC05924)
Fournisseur:
STEMCELL Technologies
Description:
Integrated workflow containing tools to isolate and expand erythroid progenitor cells from peripheral blood and their subsequent reprogramming to iPS cells.
UOM:
1 * 1 KIT
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Fournisseur:
STEMCELL Technologies
Description:
For digestion of DNA.
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