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Tonbo Biosciences
Numéro de catalogue:
(70-5898-U100)
Fournisseur:
Tonbo Biosciences
Description:
The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.
UOM:
1 * 1 EA
Numéro de catalogue:
(70-1271-U100)
Fournisseur:
Tonbo Biosciences
Description:
The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.
UOM:
1 * 1 EA
Numéro de catalogue:
(70-0459-U100)
Fournisseur:
Tonbo Biosciences
Description:
The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.
UOM:
1 * 1 EA
Fournisseur:
Tonbo Biosciences
Description:
The 30-H12 antibody reacts with mouse CD90.2 (Thy1.2). CD90.2 is a strain-specific allelic form of the GPI-linked membrane associated protein CD90 and is involved in adhesion and signal transduction. CD90.2 is expressed on thymocytes, mature T cells and neurons in mouse strains that express the CD90.2 allele (BALB/c, CBA, C3H, C57BL/6, SJL and others). 30-H12 does not react with the CD90.1 allele expressed in mouse strains such as PL and AKR.
Fournisseur:
Tonbo Biosciences
Description:
The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will compete for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.
Fournisseur:
Tonbo Biosciences
Description:
The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will "compete" for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.
Fournisseur:
Tonbo Biosciences
Description:
The 2.4G2 antibody is specific for a common epitope found in the extracellular regions of mouse Fc-receptors Fc-gamma II (CD32) and Fc-gamma III (CD16). These receptors are expressed by B cells, monocytes, macrophages, NK cells, dendritic cells, and neutrophils.
Numéro de catalogue:
(72-8090-M001)
Fournisseur:
Tonbo Biosciences
Description:
Donkey anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/bovine, chicken, goat, guinea pig, hamster, horse, human, rabbit, rat or sheep IgG
UOM:
1 * 1 mg
Numéro de catalogue:
(70-8075-M001)
Fournisseur:
Tonbo Biosciences
Description:
Rabbit anti-Human IgM (mu chain) - Affinity Pure
UOM:
1 * 1 mg
Numéro de catalogue:
(72-8042-M001)
Fournisseur:
Tonbo Biosciences
Description:
Goat anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate
UOM:
1 * 1 mg
Numéro de catalogue:
(35-8068-M001)
Fournisseur:
Tonbo Biosciences
Description:
Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/ bovine, goat, human, mouse or rat IgG or serum
UOM:
1 * 1 mg
Numéro de catalogue:
(35-8066-M002)
Fournisseur:
Tonbo Biosciences
Description:
Goat anti-Mouse IgM (mu chain) - Affinity Pure, FITC Conjugate, min x w/human IgG or serum proteins
UOM:
1 * 2 mg
Numéro de catalogue:
(35-8077-M002)
Fournisseur:
Tonbo Biosciences
Description:
Rabbit anti-Mouse IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/human serum proteins
UOM:
1 * 2 mg
Numéro de catalogue:
(22-8067-M001)
Fournisseur:
Tonbo Biosciences
Description:
Goat anti-Rabbit IgG (H&L) - Affinity Pure, Alkaline Phosphatase Conjugate
UOM:
1 * 1 mg
Numéro de catalogue:
(72-8104-M001)
Fournisseur:
Tonbo Biosciences
Description:
Goat anti-Rat IgG (H&L) - Affinity Pure, HRP Conjugate
UOM:
1 * 1 mg
Numéro de catalogue:
(35-8015-U500)
Fournisseur:
Tonbo Biosciences
Description:
Goat anti-Human IgA (alpha chain), F(ab')2 Fragment - Affinity Pure, FITC Conjugate
UOM:
1 * 0,5 mg
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