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Anticorps
Numéro de catalogue:
(ENZOALX804448C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rat, Isotype: IgG1
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX804421R100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AhR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the Ah Receptor.
Studies indicate that in non-ligand activated cells, AhR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). The AhR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.
UOM:
1 * 100 µl
New Product
Numéro de catalogue:
(ENZOALX804353C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rat, Isotype: IgG2a
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX804355C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rat, Isotype: IgG2a
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX804868C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Chemerin (tazarotene-induced gene 2; TIG2) is a chemotactic agent that was identified as the ligand for the orphan G protein-coupled receptor ChemR23. Chemerin has been shown to be expressed abundantly in adipose tissue and to function as a adipokine. Chemerin potentiates insulin-stimulated glucose uptake and regulates adipogenesis and adipocyte metabolism.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX805046BC050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rat, Isotype: IgG2a
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOADIAAM140E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Bax is an appromimately 22 kDa pro-apoptotic protein belonging to the Bcl-2 family of proteins, which are characterised by the presence of atleast one Bcl-2 homology (BH) domains.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
Fournisseur:
ENZO LIFE SCIENCES
Description:
The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
Numéro de catalogue:
(ENZOADIAAM020E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Osteoprotegerin (OPG) is a secreted glycoprotein belonging to the TNF receptor (TNF-R) superfamily that functions as a decoy receptor for RANK-Ligand (RANKL/OPGL). Unlike other TNF-Rs, OPG lacks a membrane-anchoring hydrophobic domain and lacks any apparent cell-associated signaling capability. OPG secreted by osteoblasts competes with RANK (expressed on osteoblast precursors) for binding to RANKL, blocking osteoclastogenesis and increasing bone density.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Nuclear factor kappa-B (NFk) B) functions as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NF-kB is a heterodimer consisting of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA) (ref. 3), both of which exhibit sequence homology to the protooncogene c-Rel. p50 has an isoform called p49/p52, and both proteins derive from the amino-terminal of precursor protein p105 and p100, respectively. The p50/p65 heterodimer remains in inactive form in the cytosol as a complex with its inhibitor, IkB. Upon stimulation of cells by a variety of stimuli, including lipopolysaccharide (LPS), pro-inflammatory cytokines like interleukin-1 and tumor necrosis factor, and viral infection, IkB becomes phosphorylated and degraded by the proteosome. The active NF-kB heterodimer translocates into the nucleus and induces gene expression.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.
Numéro de catalogue:
(ENZOADINBA202200)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Anti-SMN1 Mouse Monoclonal Antibody [clone: 2B1]
UOM:
1 * 200 µG
New Product
Numéro de catalogue:
(ENZOADIMSA150E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Thioredoxins act as antioxidants by reducing the proteins by cysteine thiol-disulfide exchange. Several plasmid expression vectors have been constructed that direct the synthesis of foreign polypeptides in E. coli as fusions with C-terminal Thioredoxin (TrxA) to offer soluble expression of normally insoluble or difficult to express proteins such as cytokines and growth factors.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cytochrome p450 is a highly conserved and diverse family of heme-containing proteins that function in the metabolism of numerous endogenous and exogenous substrates.
Numéro de catalogue:
(NOVUNBP1-72795)
Fournisseur:
Novus Biologicals
Description:
Rabbit Polyclonal Rabbit anti-Mouse IgG2b Antibody. Tested Applications: Western Blot, ELISA, Immunohistochemistry. Tested Reactivity: Mouse.
UOM:
1 * 1 mg
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