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Protéines et Peptides
Numéro de catalogue:
(PRSI2127P)
Fournisseur:
ProSci Inc.
Description:
MyD88 peptide is used for blocking the activity of MyD88 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-001)
Fournisseur:
ProSci Inc.
Description:
Human Granulocyte-Colony-Stimulating Factor (G-CSF) is 20 kD glycoprotein containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and it functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5527P)
Fournisseur:
ProSci Inc.
Description:
RHBDD2 peptide is used for blocking the activity of RHBDD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-072)
Fournisseur:
ProSci Inc.
Description:
Nucelobindin-2 (NUCB2; Nesfatin-1) was first isolated in adipocytes, but is also expressed by gastric mucosa and pancreatic beta cells. This pattern of nucleobindin-2 expression, as well as the presence of nucelobindin-2 within the plasma of rodents and humans, strongly suggests that this compound may act as a circulating regulatory factor. Nucelobindin-2 is reported to reduce food intake after administration. It is responsible for regulating appetite and production of body fat. Excess nucelobindin-2 in the brain leads to a loss of appetite, lack of nesfatin-1 in the brain leads to an increase of appetite.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-611)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-610)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI7015P)
Fournisseur:
ProSci Inc.
Description:
CDKN1C peptide is used for blocking the activity of CDKN1C antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4343P)
Fournisseur:
ProSci Inc.
Description:
CDNF peptide is used for blocking the activity of CDNF antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4351P)
Fournisseur:
ProSci Inc.
Description:
LGP2 peptide is used for blocking the activity of LGP2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4341P)
Fournisseur:
ProSci Inc.
Description:
TEM7 peptide is used for blocking the activity of TEM7 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4347P)
Fournisseur:
ProSci Inc.
Description:
MANF peptide is used for blocking the activity of MANF antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4349P)
Fournisseur:
ProSci Inc.
Description:
MANF peptide is used for blocking the activity of MANF antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-373)
Fournisseur:
ProSci Inc.
Description:
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-434)
Fournisseur:
ProSci Inc.
Description:
Serpin B9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. Serpin B9 is an inhibitor of the granzyme B/perforin lytic pathway. It is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodelling, and apoptosis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5047P)
Fournisseur:
ProSci Inc.
Description:
CDIP peptide is used for blocking the activity of CDIP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5057P)
Fournisseur:
ProSci Inc.
Description:
FNIP2 peptide is used for blocking the activity of FNIP2 antibody.
UOM:
1 * 50 µG
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