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Protéines et Peptides
Numéro de catalogue:
(PRSI91-834)
Fournisseur:
ProSci Inc.
Description:
Dickkopf-related protein 2 (DKK2), is a member of the dickkopf family. DKK2 is secreted protein which contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-832)
Fournisseur:
ProSci Inc.
Description:
IL-21 induces the production of IgG1 and IgG3 in B-cells. IL-21 may promote the transition between innate and adaptive immunity. IL-21 may have a role in proliferation and maturation of natural killer cells in synergy with IL15. IL-21 stimulates interferon gamma production in T-cells and natural killer cells by synergy with IL15 and IL18. Dysregulation of IL-21 has a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-160)
Fournisseur:
ProSci Inc.
Description:
Thymopentin is a member of the LEM family. Thymopentin is expressed in many tissues, highly in the adult thymus and fetal liver. The N-terminal contains two structurally independent domains, LEM domain and LEM-like domain. The C-terminal domain forms a four-stranded coiled coil. Thymopentin may be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. It is associated with T-cell development and function. Meantime, Thymopentin plays an important role, together with LMNA, in the nuclear anchorage of RB1. Thymopoietin is participated in the induction of CD90 in the thymus.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4111P)
Fournisseur:
ProSci Inc.
Description:
ORAI2 peptide is used for blocking the activity of ORAI2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5681P)
Fournisseur:
ProSci Inc.
Description:
TMEM184A peptide is used for blocking the activity of TMEM184A antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3551P)
Fournisseur:
ProSci Inc.
Description:
Adiponectin peptide is used for blocking the activity of the adiponectin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3533P)
Fournisseur:
ProSci Inc.
Description:
SARS envelope peptide is used for blocking the activity of the SARS envelope antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4801P)
Fournisseur:
ProSci Inc.
Description:
Akirin1 peptide is used for blocking the activity of Akirin1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4793P)
Fournisseur:
ProSci Inc.
Description:
ACVR1B peptide is used for blocking the activity of ACVR1B antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4041P)
Fournisseur:
ProSci Inc.
Description:
ORAI1 peptide is used for blocking the activity of ORAI1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-534)
Fournisseur:
ProSci Inc.
Description:
EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. EDIL3 has been found to be re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence and migration of endothelial cells, and acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. EDIL3 has also been shown to be an endogenous inhibitor of inflammatory cell recruitment by interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion. Human EDIL3 is synthesized as a precursor with a 16 amino acid signal sequence and a 464 amino acid mature chain.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI40-123)
Fournisseur:
ProSci Inc.
Description:
GLP-1 is a proglucagon-derived peptide hormone secreted primarily by intestinal L cells during feeding. Its major physiological function is stimulation of pancreatic β-cells to release appropriate amounts of insulin after glucose absorption. Other biological actions exhibited by GLP-1 include suppression of plasma glucagons levels, inhibition of gastric motility, and promotion of satiety. The secretion of GLP-1 from intestinal L cells is stimulated by nutrients, hormones, and neural inputs. On the other hand, insulin has been reported to inhibit GLP-1 release, indicating that a feedback loop mechanism regulates GLP-1 secretion. In addition to being the precursor of GLP-1, proglucagon, whose primary structure is highly conserved in mammalian species, is also the precursor for other members of the glucagon family of peptide hormones including glicentin-related pancreatic peptide (GRPP), glucagons, and GLP-2. Recombinant human GLP-1 is a 3.3 kDa consisting of 31 amino acid residues.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI5443P)
Fournisseur:
ProSci Inc.
Description:
GOLPH3 peptide is used for blocking the activity of GOLPH3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-266)
Fournisseur:
ProSci Inc.
Description:
BCMA is a receptor for BAFF and APRIL. It promotes B cell survival and plays a role in the regulation of humoral immunity. Its downstream signalling is dependent on NF-kappaB and JNK.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-275)
Fournisseur:
ProSci Inc.
Description:
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5511P)
Fournisseur:
ProSci Inc.
Description:
CCDC47 peptide is used for blocking the activity of CCDC47 antibody.
UOM:
1 * 50 µG
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