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Antilichamen
Itemnummer:
(ENZOALX804126C100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Clusterin (SGP-2/sulfated glycoprotein-2; CLI; Apolipoprotein J (Apo J); TRPM-2) is the first identified extracellular mammalian chaperone and appears to be implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodelling and lipid transport. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. A dual role has been shown for clusterin in that cells can be protected from damage and dead cells can be more easily removed after some types of cellular damage.
UOM:
1 * 1 EA
New Product
Itemnummer:
(ENZOALX804177C050)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
VASP (vasodilator stimulated phosphoprotein) is a proline-rich protein substrate of cAMP- and cGMP-dependent protein kinases. Phosphorylation of VASP at Ser-157 causes a mobility shift in SDS gel electrophoresis from 46 to 50 kDa, which has been used as a convenient marker to monitor cyclic nucleotide-dependent protein kinase activity. VASP is the founding member of the Ena-VASP protein family, comprising the Drosophila protein Enabled (Ena), its mouse homologue Mena (mammalian Enabled), and mouse EVL (Ena-VASP-like protein). With these proteins VASP shares a conserved overall domain organization:
a) the conserved N-terminal Ena-VASP homology domain 1 (EVH1), which mediates binding to a proline-rich motif, b) a more divergent proline-rich central domain (which is responsible for profilin binding), and c) a conserved C-terminal EVH2 domain. Particularly high VASP levels are present in platelets, although VASP is expressed in a wide variety of cell types and tissues. In cultured cells, VASP is associated with focal adhesions, cell-cell contacts, microfilaments, and highly dynamic membrane regions. From in vitro binding data VASP has been suggested to link profilin to zyxin, vinculin, and the Listeria spp. surface protein ActA, respectively. Functional evidence indicates that VASP is a crucial factor involved in the enhancement of actin filament formation and the actin-dependent motility of intracellular bacterial pathogens.
UOM:
1 * 50 µG
New Product
Itemnummer:
(ENZOALX804099R100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Host: Mouse, Isotype: IgG1
UOM:
1 * 100 µl
New Product
Itemnummer:
(ENZOALX804180C100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STAT3 is activated by tyrosine phosphorylation at residue Y705 in cells treated with interleukin-6 or EGF. Activated STAT3 can bind to DNA either as homodimer or as heterodimer with STAT1.
UOM:
1 * 1 EA
New Product
Itemnummer:
(ENZOALX804213R100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Mammalian apurinic/apyrimidinic (AP) endonuclease (APE1; APEX; HAP1; Ref-1) is a multifunctional, bipartite enzyme that belongs to the class II AP endonucleases and that plays an important role in numerous, cellular functions, like repairing abasic sites (loss of purine or pyrimidine base) in DNA, regulating the redox state of other proteins that play roles in oxidative signalling, transcription factor regulation (Fos, Jun, NF-κ B, Myb, HIF-1α, CREB, Pac), cell cycle control (p53) and apoptosis. APE1 initiates the DNA base excision repair (BER) by cleaving the DNA immediately adjacent to the 5’ of an AP site to produce a hydroxyl group at the 3’ terminus of an unmodified nucleotide upstream of the nick and a 5’-deoxyribose phosphate moiety downstream. The product of APE1 is further processed by DNA polymerase β to release 5’-deoxyribose phosphate with its intrinsic lyase activity. The nicked DNA is then sealed by DNA ligase I or DNA ligaseIII/XRCC1 to complete this repair process. In addition to the AP endonuclease activity, APE1 also possesses a 3’-5’ DNA exonuclease activity, a 3’-phosphodiesterase activity, a 3’-phosphatase activity, and a RNase H activity. It has been shown that APE1 is capable of excision L-configuration deoxyribonucleoside analogs from the 3’ termini of DNA. Human APE1 gene is located on chromosome 14q 11.2-12.
UOM:
1 * 100 µl
New Product
Itemnummer:
(ENZOALX804244C100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
RANKL (TRANCE, OPGL, ODF) is a member of the TNF family. RANKL (receptor activator of NF-κB ligand) or TRANCE (TNF-related activation-induced cytokine receptor) has been implicated in interactions between T cells and dendritic cells. RANKL binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. RANKL is also important in T- and B-cell maturation. As OPGL (osteoprotegerin ligand) or ODF (osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. RANKL deficient mice show severe osteoporesis and complete abscence of osteoclasts as a result of lack of osteogenesis.
UOM:
1 * 1 EA
New Product
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
Itemnummer:
(20884-100UL)
Leverancier:
Biotium
Omschrijving:
Goat anti-alpaca IgG antibody that recognizes the VHH domain of heavy chain alpaca IgG. Labeled with CF® Dyes and suitable for western or IF applications.
UOM:
1 * 1 Un.
New Product
Itemnummer:
(ENZOENZABS2270100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Recommended Applications: Flow Cytometry, WB, FUNC
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Itemnummer:
(ENZOENZABS2190100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Recommended Applications: ELISA, ICC, IHC, WB
Species reactivity: Mammalian
UOM:
1 * 100 µl
New Product
Itemnummer:
(ENZOENZABS2260100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Recommended Applications: ELISA, IP, WB
Species reactivity: Human, Mouse
UOM:
1 * 1 EA
New Product
Itemnummer:
(ENZOENZABS2440100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Recommended Applications: Flow Cytometry
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Itemnummer:
(ENZOENZABS1580100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Recommended Applications: Flow Cytometry
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Itemnummer:
(ENZOENZABS2460100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Recommended Applications: Flow Cytometry
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Anti-HSP90A Rabbit Polyclonal Antibody
Itemnummer:
(ENZOADISRA1000D)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
The Estrogen receptors (ER), mainly ERalpha and ERbeta, are members of the nuclear steroid hormone receptor family and are composed of three domains, an N-terminal domain required for maximal transactivation function (TAF), a DNA binding domain, and a steroid binding domain. Estrogen has pleiotropic effects on the growth, development, and maintenance of diverse tissues.
UOM:
1 * 50 µG
New Product
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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