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Antilichamen
Itemnummer:
(BOSSBS-10271R-HRP)
Leverancier:
Bioss
Omschrijving:
The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge; Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-3067R-HRP)
Leverancier:
Bioss
Omschrijving:
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-12188R-A750)
Leverancier:
Bioss
Omschrijving:
Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-9009R-A488)
Leverancier:
Bioss
Omschrijving:
Transportin 1 is the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. In cases of HIV-1 infections, transportin 1 is known to bind and mediate the nuclear import of HIV-1 Rev.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-12188R-HRP)
Leverancier:
Bioss
Omschrijving:
Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-12189R-CY5)
Leverancier:
Bioss
Omschrijving:
DDX3 is involved in RNA metabolism. Two DDX3 paralogs are found in humans; DDX3X is encoded by a gene found on the X chromosome while DDX3Y is encoded by a gene on the Y chromosome. DDX3Y is exclusively expressed in testis and is required for normal spermatogenesis. DDX3X is ubiquitously expressed and predominantly localizes to the nuclear speckles, participating in RNA splicing, transcription, translation initiation, mRNA transport and cell cycle regulation. DDX3X also partakes in HIV-1 replication and hepatitis C viral infections.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-13349R-A350)
Leverancier:
Bioss
Omschrijving:
g-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of Glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts Leukotriene C4 to Leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and tissues there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-13349R-A647)
Leverancier:
Bioss
Omschrijving:
g-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of Glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts Leukotriene C4 to Leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and tissues there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-2397R-CY3)
Leverancier:
Bioss
Omschrijving:
Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-2469R-HRP)
Leverancier:
Bioss
Omschrijving:
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity).
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-2397R-A555)
Leverancier:
Bioss
Omschrijving:
Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0791R-CY5.5)
Leverancier:
Bioss
Omschrijving:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0791R-CY7)
Leverancier:
Bioss
Omschrijving:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0799R-CY3)
Leverancier:
Bioss
Omschrijving:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-13448R-FITC)
Leverancier:
Bioss
Omschrijving:
GLYCTK is a 523 amino acid protein that is expressed as seven isoforms which are present throughout the body. Localized to the cytoplasm and the mitochondrion in an isoform-specific manner, GLYCTK functions to catalyze the ATP-dependent conversion of (R)-glycerate to 3-(R)-glycerate, thereby playing an important role in neural and skeletal muscle systems. Defects in the gene encoding GLYCTK are the cause of D-glyceric acidemia, an inborn error of amino acid metabolism that is best described as nonketotic hyperglycinemia and is characterized by the excretion of D-glyceric acid in the urine.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-6051R-A680)
Leverancier:
Bioss
Omschrijving:
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits <i>in vivo</i> proliferation of colon cancer cells.
UOM:
1 * 100 µl
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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