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Antilichamen
Leverancier:
Biotium
Omschrijving:
Recognizes a protein of 40 kDa, identified as CD7, a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
Itemnummer:
(USBIA0876-45B)
Leverancier:
US Biological
Omschrijving:
Anti-Adenovirus Mouse Monoclonal Antibody [clone: 10K1]
UOM:
1 * 1 mg
Itemnummer:
(USBIA0880-04F)
Leverancier:
US Biological
Omschrijving:
Anti-Adenovirus, Hexon Mouse Monoclonal Antibody [clone: 10B62]
UOM:
1 * 1 mL
Itemnummer:
(USBIA0880-04B)
Leverancier:
US Biological
Omschrijving:
Anti-Adenovirus hexon Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: 9L8]
UOM:
1 * 1 EA
Itemnummer:
(USBIS1013-15C)
Leverancier:
US Biological
Omschrijving:
Anti-Shigella sp. Rabbit Polyclonal Antibody (FITC (Fluorescein))
UOM:
1 * 1 mL
Leverancier:
Biotium
Omschrijving:
This antibody recognizes an oncofetal glycoprotein with a single chain of 70 kDa, which is identified as alpha-fetoprotein (AFP) (ISOBM TD-2 workshop). This MAb is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
Leverancier:
Biotium
Omschrijving:
Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
Leverancier:
Biotium
Omschrijving:
This MAb recognizes a protein of ~50 kDa which is identified as Glial Fibrillary Acidic Protein (GFAP). It shows no cross-reaction with other intermediate filament proteins. GFAP is specifically found in astroglia. GFAP is a very popular marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system. Antibody to GFAP is useful in differentiating primary gliomas from metastatic lesions in the brain and for documenting astrocytic differentiation in tumors outside the CNS.
Leverancier:
Biotium
Omschrijving:
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
Leverancier:
Biotium
Omschrijving:
MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. Anti-MITF, D5, recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.
Itemnummer:
(USBIP4073-14D-FITC)
Leverancier:
US Biological
Omschrijving:
Anti-PGK2 Rabbit Polyclonal Antibody (FITC (Fluorescein))
UOM:
1 * 200 µl
Itemnummer:
(USBIP9545-03-PE)
Leverancier:
US Biological
Omschrijving:
Anti-PKLR Rabbit Polyclonal Antibody (PE (Phycoerythrin))
UOM:
1 * 200 µl
Itemnummer:
(USBIP4073-14D-APC)
Leverancier:
US Biological
Omschrijving:
Anti-PGK2 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
UOM:
1 * 200 µl
Itemnummer:
(USBIQ0500-01E-FITC)
Leverancier:
US Biological
Omschrijving:
Anti-QKI Rabbit Polyclonal Antibody (FITC (Fluorescein))
UOM:
1 * 200 µl
Itemnummer:
(USBIP9545-31H-FITC)
Leverancier:
US Biological
Omschrijving:
Anti-PKM Rabbit Polyclonal Antibody (FITC (Fluorescein))
UOM:
1 * 200 µl
Itemnummer:
(USBIP9545-31F-FITC)
Leverancier:
US Biological
Omschrijving:
Anti-PKM Rabbit Polyclonal Antibody (FITC (Fluorescein))
UOM:
1 * 200 µl
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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