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Antilichamen
Itemnummer:
(BOSSBS-6479R-CY7)
Leverancier:
Bioss
Omschrijving:
Myotilin, a sarcomeric protein that is encoded by the gene mapping to human chromosome 5q31, binds to a-actinin and is localized in the Z-line of myofibrils. Myotilin is expressed in skeletal and cardiac muscle, and it co-localizes with a-actinin in the sarcomeric I-bands where it directly interacts with a-actinin. Defects in the myotilin gene are reported to cause a form of autosomal dominant limb-girdle muscular dystrophy (LGMD). Symptoms of adult onset LGMD are progressive weakness of the hip and shoulder girdles as well as a distinctive dysarthric pattern of speech. The muscle of affected individuals with LGMD shows degeneration of myofibers, variations in fiber size, fiber splitting, centrally located myonuclei and an enhanced number of autophagic vesicles.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-10156R-CY3)
Leverancier:
Bioss
Omschrijving:
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8405R-A680)
Leverancier:
Bioss
Omschrijving:
GFOD2 is a 385 amino acid secreted protein of the extracellular matrix that belongs to the gfo/idh/mocA family. Existing as two alternatively spliced isoforms, GFOD2 enhances matrix assembly and is encoded by a gene that maps to human chromosome 16q22.1. Chromosome 16 encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterised by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-4246R-CY5)
Leverancier:
Bioss
Omschrijving:
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-6981R-CY5.5)
Leverancier:
Bioss
Omschrijving:
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-3255R-CY7)
Leverancier:
Bioss
Omschrijving:
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Itemnummer:
(IMMRGT-003-ZBIO)
Leverancier:
ImmunoReagents
Omschrijving:
Anti-IgG Goat Polyclonal Antibody (Biotin)
UOM:
1 * 1 mg
Itemnummer:
(BOSSBS-1540R-CY3)
Leverancier:
Bioss
Omschrijving:
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-1540R-A555)
Leverancier:
Bioss
Omschrijving:
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-7709R-FITC)
Leverancier:
Bioss
Omschrijving:
Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.Tissue specificity:Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-7709R-CY3)
Leverancier:
Bioss
Omschrijving:
Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.Tissue specificity:Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-1322R-FITC)
Leverancier:
Bioss
Omschrijving:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-5654R-CY5)
Leverancier:
Bioss
Omschrijving:
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq].
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-2654R-A750)
Leverancier:
Bioss
Omschrijving:
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8259R-FITC)
Leverancier:
Bioss
Omschrijving:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-2655R-CY5)
Leverancier:
Bioss
Omschrijving:
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 >12-epi-LTB4 >LTB5 >LTB3.
UOM:
1 * 100 µl
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
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