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Ace+Method+Development+Kits
Numéro de catalogue:
(PRSI38-157)
Fournisseur:
ProSci Inc.
Description:
GDF3 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. The function of this protein is unknown, but expression studies suggest it may be involved in regulation of the adult lymphatic and erythroid systems and embryonic development.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXPS-2019)
Fournisseur:
ProSci Inc.
Description:
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXPS-2024)
Fournisseur:
ProSci Inc.
Description:
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR2A subunit of the receptor has been associated synaptic plasticity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI33-453)
Fournisseur:
ProSci Inc.
Description:
Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterised by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognises target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(REST36005)
Fournisseur:
Restek
Description:
The test for ethylene oxide is specified in many individual drug monographs of USP24/NF19. The limit test concentration is currently 10 ppm. While the specific test solution and method will vary depending on the particular drug monograph, the solution below is suitable for most tests.
UOM:
1 * 1 ST
Numéro de catalogue:
(PRSI79-779)
Fournisseur:
ProSci Inc.
Description:
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK.
UOM:
1 * 1 EA
Fournisseur:
STEMCELL Technologies
Description:
Insulin-like growth factor 2 (IGF-II) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-II binding to IGF-I receptor activates a signaling cascade via the MAPK and PI3K pathways. IGF-II affects growth, differentiation, and survival of cells in a variety of tissues during embryonic development. It stimulates proliferation and migration of primary lymphatic endothelial cells, and induces lymphangiogenesis (Guvakova).
Numéro de catalogue:
(PRSI76-183)
Fournisseur:
ProSci Inc.
Description:
The Eat-2 monoclonal antibody reacts with mouse CD81, a 26 kDa non-glycosylated transmembrane protein. CD81 is expressed broadly on B cells, T cells, NK cells, dendritic cells, fibroblasts, and endothelial cells. It plays a role in T cell development and is involved in B and T cell adhesion. The Eat-2 antibody is also reported to cross-react with the rat CD81 antigen.
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI92-477)
Fournisseur:
ProSci Inc.
Description:
Transforming growth factor beta-2 (TGF- beta 2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumours. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD).
UOM:
1 * 50 µG
Fournisseur:
Shenandoah Biotechnology
Description:
Fibroblast growth factor 4 (FGF-4) is a secreted growth factor that is predominantly expressed during bone morphogenesis and embryonic limb development. FGF-4 is an important growth regulator for stem cells, fibroblasts, and endothelial cells. FGF-4 contains a single N-linked glycosylation signal. In-vitro studies suggest that unglycosylated FGF-4 is cleaved into 13 kDa and 15 kDa truncated proteins that have greater biological activity than the wild type 19 kDa FGF-4 protein. Human FGF-4 shares high homology and is cross-reactive with mouse FGF-4.
Fournisseur:
STEMCELL Technologies
Description:
Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>).
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