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Masterflex+Single-use+Flow+Sensor


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Numéro de catalogue: (PRSI96-660)

Fournisseur:  ProSci Inc.
Description:   R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furinlike domains are needed for β-catenin stabilisation. A putative nuclear localisation signal at the C-terminus may allow some expression in the nucleus. Potential isoforms of 200 and 236 aa have an alternate, shorter N-terminus or are missing aa 146-208, respectively. R-Spondin-1 is expressed in early development at the roof plate boundary and is thought to contribute to dorsal neural tube development. Human RSPO1 disruption results in a recessive syndrome characterized by XX sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. It has been shown that the complete female-to-male sex reversal is due to the absence of the testis-determining gene, SRY. R-Spondin-1 regulates Wnt/β-catenin by competing with the Wnt antagonist DKK1 for binding to the Wnt co receptors, Kremen and LRP6, reducing their DKK1 mediated internalisation. Reports differ on whether R-spondin 1 binds LRP6 directly.
UOM:  1 * 50 µG
Numéro de catalogue: (METN51109295)

Fournisseur:  Mettler - Toledo
Description:   Reference electrode with break-proof plastic shaft and S7 connector.
UOM:  1 * 1 ST
Fournisseur:  SI Analytics
Description:   Reference electrodes with glass shaft.

Fournisseur:  Thermo Orion
Description:   This portable meter armor adds protection around the meter screen and includes a hand or belt strap that can be converted to built-in stand, pH electrode holder, conductivity and DO probe holder and pH electrode storage sleeve.
UOM:  1 * 1 ST
Numéro de catalogue: (BARN88880005)

Fournisseur:  Thermo Fisher Scientific
Description:   The RT2 is alow-profile digital display hotplatestirrer, equipped with PT100 sensor for precise temperature measurements for sensitive experimental procedures with built-in temperature shut-off to heat samples safely and accurately. The aluminium top provides excellent temperature uniformity while the thin ceramic coating provides excellent corrosion resistance and a white surface for optimal sample viewing. The unit features a keypad lock, hot top warning indicator and has two threaded holes to accommodate support rods.
UOM:  1 * 1 ST
Fournisseur:  SI Analytics
Description:   Électrode, pH, L 1181 HD, pH: 0 - 12, −30...+80 °C, Verre, Membrane: -, Électrolyte: -, Ø×L: 12×120 mm, Raccord de connexion à vis
Numéro de catalogue: (PRSIPM-5205)

Fournisseur:  ProSci Inc.
Description:   ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
UOM:  1 * 1 EA
Fournisseur:  BEHR
Description:   Complete compact extraction system with basic rack, heating device, holder, tubing and glassware (reaction flasks, extractor, Dimroth condenser for extraction).
Fournisseur:  PERSONNA MEDICAL
Description:   Razor blades for catheter cutting or cleanroom applications.

Fournisseur:  ProSci Inc.
Description:   This antibody is specific for a 17-26 kDa protein, which is identified as the cytokine TNF alpha (Tumor Necrosis Factor alpha). It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. It is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. It exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
UOM:  1 * 1 EA
New Product
Fournisseur:  Sartorius
Description:   Chaque kit se compose d'un tampon de Ø 50 mm ou Ø 47 mm, imprégné de milieu nutritif, emballé sec et stérile dans une boîte de Petri, avec un filtre à membrane. Après filtration de l'échantillon, la membrane est placée dans la boîte et incubée. Autres types disponibles sur demande.
UOM:  1 * 100 ST
Numéro de catalogue: (PRSI91-811)

Fournisseur:  ProSci Inc.
Description:   CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains one Ig-like C2-type domain and one Ig-like V-type domain, but does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. CD48 may facilitate interaction between activated lymphocytes and be involved in regulating T-cell activation. CD48 plays a vital role as an environmental sensor for regulating progenitor cell numbers and inhibiting tumor development. It is suggested that the anti-CD48 mAb has the potential to become an effective therapeutic mAb against multiple myeloma.
UOM:  1 * 50 µG
Fournisseur:  EUTECH
Description:   Ces testeurs robustes et conviviaux sont équipés d'un affichage simultané du pH et de la température, et garantissent des mesures précises pour l'analyse de l'eau. Disponibles en version standard ou avec un capteur à pores ouverts et à pointe effilée pour les mesures directes d'échantillons solides ou semi-solides, comme du fromage, de la viande, des fruits, du pain et bien plus encore.
Numéro de catalogue: (PRSI90-393)

Fournisseur:  ProSci Inc.
Description:   CD28 and CTLA-4 together with their ligands, CD80 (B7-1) and CD86 (B7-2), constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD28 and CTLA-4 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD28 and CTLA-4 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2 and mouse chromosome 1. Mouse CD28 is expressed constitutively on virtually 100% of mouse T cells and on developing thymocytes. Cell surface expression of mouse CD28 is downregulated upon ligation of CD28 in the presence of PMA or PHA. In contrast, CTLA-4 is not expressed constitutively but is upregulated rapidly following T cell activation and CD28 ligation. Cell surface expression of mouse CTLA-4 peaks approx.y 48 hours after activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28. CD28/B7 interaction has been shown to prevent apoptosis of activated T cells via the upregulation of bcl-XL. CD28 ligation has also been shown to regulate Th1/Th2 differentiation.
UOM:  1 * 200 µG
Numéro de catalogue: (SIMETE1006)

Fournisseur:  Industrial Physics
Description:   This infrared thermometer is designed to measure surface temperatures under harsh industrial conditions without the need to make contact with the object. Typical applications are surfaces that are hard to reach, moving objects or electrical parts, parts in curing ovens, bearings, electrical junctions boxes, coolants, engines, plastic moulding, asphalt etc.
UOM:  1 * 1 ST
Numéro de catalogue: (PRSI5577)

Fournisseur:  ProSci Inc.
Description:   LXR-A Antibody: LXR-A belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-B, LXR-A forms heterodimers with the retinoic acid receptor RXRalpha, function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Human and mouse tumors produce LXR ligands that inhibit CCR7 expression on maturing dendritic cells (DCs), thereby allowing tumor immunoescape. In mouse models, it was shown that ablating LXR-A signaling led to an immune-mediated strong inhibition of tumor growth, suggesting that manipulation of this pathway may be a viable anti-cancer approach.
UOM:  1 * 1 EA
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