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TLC+EXPLORER
Fournisseur:
Biotium
Description:
BAPTA and its derivatives are calcium chelators that are commonly used to form calcium buffers with well-defined calcium concentrations. By injecting the chelators into cells or by incubating cells with the AM ester form of the chelators, one can control the cytosolic calcium concentration, an important means to study the roles of calcium.
Numéro de catalogue:
(90040.)
Fournisseur:
Biotium
Description:
5-(and-6)-Carboxy-2′,7′-dichlorofluorescein diacetate, succinimidyl ester is a useful fluorescent tracer that can passively diffuse into cells and covalently label intracellular proteins, resulting in long-term cell labeling. The reagent itself is colorless and nonfluorescent but becomes brightly green fluorescent once it is hydrolyzed by intracellular esterases.
UOM:
1 * 25 mg
Numéro de catalogue:
(ENZOBMLFR1000100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Blocks lipid peroxidation
UOM:
1 * 100 mg
New Product
Numéro de catalogue:
(50005.)
Fournisseur:
Biotium
Description:
Difluoro BAPTA AM ester is a membrane permeable form of Difluoro BAPTA that can be loaded into cells by incubation. Difluoro BAPTA AM ester itself does not bind calcium, but once inside the cell is converted into Difluoro BAPTA by cytoplasmic esterases. See #50006 for information on Difluoro BAPTA.
UOM:
1 * 25 mg
Numéro de catalogue:
(ENZOBMLEI3580005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
DuP-697 is a highly selective and irreversible inhibitor of cyclooxygenase-2 (COX-2). (COX-2 IC50=10 nm, COX-1 IC50=800 nm). It is an orally effective anti-inflammatory, analgesic and antipyretic agent which is not ulcerogenic. Inhibition of COX-2 by DuP-697 and other inhibitors exacerbates ischemia-induced myocardial dysfunction in the rabbit. It inhibits angiogenesis and induces apoptosis in human endothelial cells.
UOM:
1 * 5 mg
New Product
Numéro de catalogue:
(50003.)
Fournisseur:
Biotium
Description:
BAPTA and its derivatives are calcium chelators that are commonly used to form calcium buffers with well-defined calcium concentrations. By injecting the chelators into cells or by incubating cells with the AM ester form of the chelators, one can control the cytosolic calcium concentration, an important means to study the roles of calcium.
UOM:
1 * 1 g
Numéro de catalogue:
(90022.)
Fournisseur:
Biotium
Description:
5(6)-TAMRA SE (full name: 5-(and-6)-Carboxytetramethylrhodamine succinimidyl ester (mixed isomers)) is the amine reactive form of TAMRA, one of the most commonly used red fluorescent dyes. The succinimidyl ester reacts readily with primary or secondary amines under mild conditions.
UOM:
1 * 25 mg
Numéro de catalogue:
(ENZOBMLEI3270025)
Fournisseur:
ENZO LIFE SCIENCES
Description:
URB-597 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide. Inhibition of FAAH may serve to enhance the analgesic effects of endogenous cannabinoids. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes and in intact neurons with IC50 values of 4.6nM and 0.5nM, respectively. The compound has also been shown to have anxiolytic effects in rats (ID50=0.15mg/kg). Because URB-597 acts on FAAH and does not interfere with the binding of anandamide to the CB1 and CB2 receptors, it is a novel tool for drug development.
UOM:
1 * 25 mg
New Product
Numéro de catalogue:
(90034.)
Fournisseur:
Biotium
Description:
Full name: 5-Carboxytetramethylrhodamine succinimidyl ester (single isomer). Amine-reactive form of carboxytetramethylrhodamine (TAMRA) single isomer.
UOM:
1 * 5 mg
Fournisseur:
ENZO LIFE SCIENCES
Description:
Irreversible, cell permeable broad-spectrum caspase inhibitor.
Fournisseur:
VWR Collection
Description:
Les couches de silice modifiées sont, selon la modification, adaptées aux éluants polaires ou non polaires ou aux mélanges d’éluants.
Numéro de catalogue:
(59003.)
Fournisseur:
Biotium
Description:
TPEN (Tetrakis-(2-pyridylmethyl)ethylenediamine) is an excellent heavy metal chelator while it does not affect Ca2 , Mg2 , Na , or K concentrations. Thus, TPEN is a useful tool to identify effects of heavy metals (Zn2 , Fe2 /Fe3 , Cu2 , and Mn2 , etc.) on fluorescent indicators of Ca2 , Mg2 , Na , or K .
UOM:
1 * 100 mg
Fournisseur:
ENZO LIFE SCIENCES
Description:
Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.
Fournisseur:
ENZO LIFE SCIENCES
Description:
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.
Fournisseur:
ENZO LIFE SCIENCES
Description:
HELSS is a potent, irreversible, mechanism-based inhibitor of Ca2+-independent PLA2 (70% inhibition at 100 nM). It possesses a 1000-fold selectivity for Ca2+-independent PLA2 vs. Ca2+-dependent PLA2 . It has been used to identify the PLA2 involved in the release of arachidonate induced by vasopressin stimulation of A-10 smooth muscle cells (IC50=1 µM). It has also been shown to inhibit the Mg2+-dependent phophatidate phosphohydrolase from P388D1 macrophages (IC50~8 µM).
Fournisseur:
ENZO LIFE SCIENCES
Description:
AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
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