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Protéines et Peptides
Numéro de catalogue:
(PRSI92-130)
Fournisseur:
ProSci Inc.
Description:
Actin-Related Protein 8 (ACTR8) is a member of the Actin family. ACTR8 is the first example in actin family that was found to be associated with mitotic chromosomes. ACTR8 plays a vital role in the functional organisation of mitotic chromosomes. This protein is a proposed core component of the chromatin remodelling INO80 complex that is involved in transcriptional regulation, DNA replication and probable DNA repair, and it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-601)
Fournisseur:
ProSci Inc.
Description:
Alpha-2-antiplasmin, also called Serpin F2, is a serine protease inhibitor (serpin) responsible for inactivating plasmin, and an important enzyme participates in fibrinolysis and degradation of other proteins. In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. Serpin F2 is major expressed on liver and kidney. Some other tissues such as muscle, intestine, central nervous system, and placenta also express Serpin F2 mRNA at a moderate level indicated that it is a key regulator of plasmin-mediated proteolysis in these tissues.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-437)
Fournisseur:
ProSci Inc.
Description:
Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-480)
Fournisseur:
ProSci Inc.
Description:
Human IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit critical for receptor-mediated signalling via physically or functionally coupling to other signalling molecules, such as the Jak-STAT and Src-family protein tyrosine kinase although it lacks apparent catalytic motifs.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-309)
Fournisseur:
ProSci Inc.
Description:
S100A6, also known as Protein S100-A6, Calcyclin, Growth factor-inducible protein 2A9, MLN 4, Prolactin receptor-associated protein, PRA, S100 calcium-binding protein A6 and CACY, is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are a family of low molecular weight protein found in vertebrates and localised in the cytoplasm and/or nucleus of a wide range of cells.S100 proteins are involved in a number of fundamental biological processes such as protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, the inflammatory response,cell cycle progression and differentiation, stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. S100A6 may function as calcium sensor and modulator, contributing to cellular calcium signaling.It may function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganisation of the actin cytoskeleton and in cell motility.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-305)
Fournisseur:
ProSci Inc.
Description:
CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such as phosphorylating and inhibiting members of the retinoblastoma (RB) protein family including RB1 and regulating the cell-cycle during G1/S transition. It is also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-465)
Fournisseur:
ProSci Inc.
Description:
Semaphorin-4G is belongs to the semaphorin family, contains 1 Ig-like C2-type domain, 1 PSI domain, 1 Sema domain. Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-468)
Fournisseur:
ProSci Inc.
Description:
Semaphorin-4C is a protein which belongs to the semaphorin family, contains 1 Ig-like C2-type domain, 1 PSI domain, 1 Sema domain. As cell surface receptor for PLXNB2, it plays an important role in cell-cell signalling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. It required for normal brain development, axon guidance and cell migration, Probable signalling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5959P)
Fournisseur:
ProSci Inc.
Description:
NALP5 peptide is used for blocking the activity of NALP5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5965P)
Fournisseur:
ProSci Inc.
Description:
NALP8 peptide is used for blocking the activity of NALP8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2129P)
Fournisseur:
ProSci Inc.
Description:
IL-1RAcP peptide is used for blocking the activity of IL-1RAcP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6791P)
Fournisseur:
ProSci Inc.
Description:
RILP peptide is used for blocking the activity of RILP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6783P)
Fournisseur:
ProSci Inc.
Description:
TMEM106B peptide is used for blocking the activity of TMEM106B antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6785P)
Fournisseur:
ProSci Inc.
Description:
AIG1 peptide is used for blocking the activity of AIG1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5509P)
Fournisseur:
ProSci Inc.
Description:
CCDC47 peptide is used for blocking the activity of CCDC47 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5525P)
Fournisseur:
ProSci Inc.
Description:
RHBDD1 peptide is used for blocking the activity of RHBDD1 antibody.
UOM:
1 * 50 µG
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