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Protéines et Peptides
Numéro de catalogue:
(PRSI7133P)
Fournisseur:
ProSci Inc.
Description:
17 amino acids near the carboxy terminus of human CHCHD6.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7117P)
Fournisseur:
ProSci Inc.
Description:
SHROOM3 Peptide is used for blocking the activity of SHROOM3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5473P)
Fournisseur:
ProSci Inc.
Description:
SRPX1 peptide is used for blocking the activity of SRPX1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-273)
Fournisseur:
ProSci Inc.
Description:
Annexin A3（ANXA3）contains 4 annexin repeats and belongs to the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. ANXA3 is Inhibitor of phospholipase A2 and cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. it also also play a role in anti-coagulant properties.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-282)
Fournisseur:
ProSci Inc.
Description:
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein, HMGB1 stabilises nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-025)
Fournisseur:
ProSci Inc.
Description:
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-023)
Fournisseur:
ProSci Inc.
Description:
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-024)
Fournisseur:
ProSci Inc.
Description:
Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-032)
Fournisseur:
ProSci Inc.
Description:
Interleukin-1 (IL-1) designates two proteins, IL-1 alpha and IL-1 beta , which are the products of distinct genes, but recognize the same cell surface receptors. IL-1 alpha and IL-1 beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa. The specific protease responsible for the processing of IL-1 beta , designated interleukin 1 beta -converting enzyme (ICE), has been described. Mature human and mouse IL-1 beta share approximately 75% amino acid sequence identity and human IL-1 beta has been found to be active on murine cell lines.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-022)
Fournisseur:
ProSci Inc.
Description:
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids with 94% identity with mouse IGF1 and exhibits cross-species activity. IGF1 binds IGF-1R, IGF-2R, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF1 expression is regulated by growth hormone.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-396)
Fournisseur:
ProSci Inc.
Description:
Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1beta and LPS. Soluble CD54 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-391)
Fournisseur:
ProSci Inc.
Description:
CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7159P)
Fournisseur:
ProSci Inc.
Description:
18 amino acids near the amino terminus of human SIDTR2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7151P)
Fournisseur:
ProSci Inc.
Description:
15 amino acids near the carboxy terminus of human MECR.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7175P)
Fournisseur:
ProSci Inc.
Description:
16 amino acids near the amino terminus of human Alpha-tubulin.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-874)
Fournisseur:
ProSci Inc.
Description:
Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.
UOM:
1 * 50 µG
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