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Protéines et Peptides
Numéro de catalogue:
(PRSI91-340)
Fournisseur:
ProSci Inc.
Description:
Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a secreted, 131 amino acid protein that contains one Ig-like C2 type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% amino acid identity across the signal sequence and extracellular domains; although one is secreted and one is membrane-bound, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. This suggests that LAIR-2 may compete with LAIR-1 for ligand binding. A 114 amino acid alternate splice form of LAIR-2 is truncated at the C terminus, but retains the entire Ig domain. The expression profile of these splice forms, and the presence of orthologs in other species, have not been reported.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-561)
Fournisseur:
ProSci Inc.
Description:
Differential screening-selected gene aberrative in neuroblastoma (DAN) is a member of the DAN family of secreted glycoproteins. DAN family antagonists are Characterised by a DAN domain that contains a cystine knot motif which is essential for binding to BMP ligands. Members of this family include DAN, gremlin, protein related to DAN and cerberus (PRDC), cerberus, sclerostin (SOST) and uterine sensitisation-associated gene 1 protein, and control diverse processes in growth, development and the cell cycle. It has also been reported that DAN family plays crucial role in early mouse embryo development by inhibiting the action of bone morphogenic proteins and modulating the action of transforming growth factor- beta superfamily members. DAN is Synthesised by small-to intermediate-sised DRG neurons and transported to the sensory nerve terminals in the skin or to the sensory nerve terminals in the dorsal horn. It has been reported that DAN is ubiquitously expressed in adult rat and human tissues. Morphological studies have revealed that, in adult rat, DAN mRNA is expressed ubiquitously in lung and brain, but not in liver.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-752)
Fournisseur:
ProSci Inc.
Description:
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) is also known as Decoy receptor 2 (DcR2), TNF-related apoptosis-inducing ligand receptor 4 (TRAIL receptor 4 or TRAIL-R4), CD264,which is the single-pass type I membrane protein. TNFRSF10D is receptor for the cytotoxic ligand TRAIL, which contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-749)
Fournisseur:
ProSci Inc.
Description:
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6975P)
Fournisseur:
ProSci Inc.
Description:
SELK peptide is used for blocking the activity of SELK antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6945P)
Fournisseur:
ProSci Inc.
Description:
DDX60 peptide is used for blocking the activity of DDX60 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5975P)
Fournisseur:
ProSci Inc.
Description:
NALP14 peptide is used for blocking the activity of NALP14 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-460)
Fournisseur:
ProSci Inc.
Description:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4685P)
Fournisseur:
ProSci Inc.
Description:
Nanos1 peptide is used for blocking the activity of Nanos1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4675P)
Fournisseur:
ProSci Inc.
Description:
BICD2 peptide is used for blocking the activity of BICD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6183P)
Fournisseur:
ProSci Inc.
Description:
VPS39 peptide is used for blocking the activity of VPS39 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-115)
Fournisseur:
ProSci Inc.
Description:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralisation. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-116)
Fournisseur:
ProSci Inc.
Description:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralisation. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4815P)
Fournisseur:
ProSci Inc.
Description:
HINT1 peptide is used for blocking the activity of HINT1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-149)
Fournisseur:
ProSci Inc.
Description:
CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-168)
Fournisseur:
ProSci Inc.
Description:
Contactin-6 is a member of the contactins, which mediate cell surface interactions during nervous system development. Contactin-6 has a key role in the formation of glutamatergic, but not GABAergic, synapses during postnatal development of the hippocampal formation as well as the cerebellum. It is involved in oligodendrocytes generation by acting as a ligand of Notch1. It is also involved in motor coordination.
UOM:
1 * 1 EA
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