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Protéines et Peptides
Numéro de catalogue:
(PRSI7325P)
Fournisseur:
ProSci Inc.
Description:
16 amino acid peptide near the carboxy terminus of human CRTC2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3649P)
Fournisseur:
ProSci Inc.
Description:
TLR5 peptide is used for blocking the activity of TLR5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-345)
Fournisseur:
ProSci Inc.
Description:
GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. It has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. It regulates Tat's transactivating activity and may help inducing chromatin remodelling of proviral genes. GCN5 is a component of the Ada Two-A containing (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4.
UOM:
1 * 2 µG
Numéro de catalogue:
(PRSI90-338)
Fournisseur:
ProSci Inc.
Description:
TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2;CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A;TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1;LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B). Trimerised TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signalling complex (DISC).
UOM:
1 * 20 µG
Numéro de catalogue:
(PRSI91-431)
Fournisseur:
ProSci Inc.
Description:
Interferon alpha/ beta Receptor 2 (IFN- alpha/ beta R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN- alpha/ beta R1 to form the signaling receptor complex for the family of alpha and beta IFN subtypes. By alternative splicing, IFN- alpha/ beta R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN- alpha/ beta R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN- alpha/ beta R1, resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets, IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-434)
Fournisseur:
ProSci Inc.
Description:
Tissue Factor (TF) is a single-pass type I membrane glycoprotein member of the tissue factor family. TF expression is highly dependent upon cell type. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. TF initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-436)
Fournisseur:
ProSci Inc.
Description:
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal storage disorders and degranulation on lymphocytes such as CD8+ and NK cells. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells(PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-830)
Fournisseur:
ProSci Inc.
Description:
Cytokine are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteine. CCL24 diaplays the chemotactic for resting T-lymphocytes and eosinophils. CCL24 has lower chemotatic activity for neutrophils, none for monocytes and activated lymphocytes. CCL24 is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell lines.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5509P)
Fournisseur:
ProSci Inc.
Description:
CCDC47 peptide is used for blocking the activity of CCDC47 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5525P)
Fournisseur:
ProSci Inc.
Description:
RHBDD1 peptide is used for blocking the activity of RHBDD1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5513P)
Fournisseur:
ProSci Inc.
Description:
PPAPDC1A peptide is used for blocking the activity of PPAPDC1A antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5589P)
Fournisseur:
ProSci Inc.
Description:
ARHGAP18 pepide is used for blocking the activity of ARHGAP18 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-280)
Fournisseur:
ProSci Inc.
Description:
IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-274)
Fournisseur:
ProSci Inc.
Description:
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-270)
Fournisseur:
ProSci Inc.
Description:
IL-1beta is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation and fibroblast growth factor activity. IL-1beta belongs to the IL-1 family of proteins that are involved in the inflammatory response. IL-1beta in most situations requires the inflammasome complex to be cleaved and secreted.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-267)
Fournisseur:
ProSci Inc.
Description:
Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Abnormal expression of Periostin is also linked to angiogenesis and metastasis in epithelial tumours.
UOM:
1 * 1 EA
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