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Protéines et Peptides
Numéro de catalogue:
(PRSI96-722)
Fournisseur:
ProSci Inc.
Description:
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-745)
Fournisseur:
ProSci Inc.
Description:
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-718)
Fournisseur:
ProSci Inc.
Description:
TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-719)
Fournisseur:
ProSci Inc.
Description:
Thrombospondin type-1 domain-containing protein 1 (THSD1) is also known as Transmembrane molecule with thrombospondin module (TMTSP), which is a single-pass type I membrane protein and contains a type 1 thrombospondin domain that is found in thrombospondin, a number of proteins involved in the complement pathway, as well as extracellular matrix proteins. In addition, THSD1 is widely expressed on endothelial cells, with highest expression in the lung. THSD1's ligand and function are unknown, but it is postulated that THSD1 may be involved in the regulation of vasculogenesis and/or angiogenesis through its interaction with its specific ligand.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-779)
Fournisseur:
ProSci Inc.
Description:
V-set and immunoglobulin domain-containing protein 2 (VSIG2) is also known as Cortical thymocyte-like protein, CTH, CTXL, is a single-pass type I membrane protein which contains Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. V-set domains are Ig-like domains resembling the antibody variable domain. VSIG2 is highly expressed in stomach, colon, prostate, trachea and thyroid glands and weakly in bladder and lung. V-set domains are found in diverse protein families, including immunoglobulin light and heavy chains.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI5987P)
Fournisseur:
ProSci Inc.
Description:
KPNA4 peptide is used for blocking the activity of KPNA4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-141)
Fournisseur:
ProSci Inc.
Description:
DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-124)
Fournisseur:
ProSci Inc.
Description:
DLL1 (Delta-like protein; Delta1) is essential for postnatal arteriogenesis and contributes to tumour progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK-cell precursor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-686)
Fournisseur:
ProSci Inc.
Description:
Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. PDGFs bind to the protein tyrosine kinase receptors PDGF receptor- alpha and - beta . These two receptor isoforms dimerise upon binding the PDGF dimer, leading to three possible receptor combinations, namely - alpha alpha, - beta beta and - alpha beta . PDGFR alpha and PDGFR beta are members of the class III RTK family. Inappropriate PDGFR alpha and PDGFR beta signalling has been linked to a number of proliferative disorders.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-683)
Fournisseur:
ProSci Inc.
Description:
Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface receptor primarily expressed on macrophages, osteoclasts, microglia and dendritic cells. TREM-2 is one member of the TREM family, inhibiting the releasing of inflammatory mediators, so it is an important in vivo anti-inflammatory receptor. TREM-2 consists of an 18 aa signal sequence, a 153 aa extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. A soluble form of TREM-2 (TREM-2b) created by alternate splicing diverges at aa 161. TREM-2 transduces intracellular signals through the adaptor DAP12. After binding of TREM-2 with ligand, the TREM-2/DAP12 (dead-cell-activated-receptor-associated protein)-mediated signal transduction pathway causes a series of intracellular protein tyrosine phosphorylation reactions and enzymatic reactions, which then activate the myeloid cells and participate T cell responses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-682)
Fournisseur:
ProSci Inc.
Description:
Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface receptor primarily expressed on macrophages, osteoclasts, microglia and dendritic cells. TREM-2 is one member of the TREM family, inhibiting the releasing of inflammatory mediators, so it is an important in vivo anti-inflammatory receptor. TREM-2 consists of an 18 aa signal sequence, a 153 aa extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. A soluble form of TREM-2 (TREM-2b) created by alternate splicing diverges at aa 161. TREM-2 transduces intracellular signals through the adaptor DAP12. After binding of TREM-2 with ligand, the TREM-2/DAP12 (dead-cell-activated-receptor-associated protein)-mediated signal transduction pathway causes a series of intracellular protein tyrosine phosphorylation reactions and enzymatic reactions, which then activate the myeloid cells and participate T cell responses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-943)
Fournisseur:
ProSci Inc.
Description:
Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon- gamma (IFN- gamma ) or type II interferon that plays an important role in activating the macrophages or other cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-947)
Fournisseur:
ProSci Inc.
Description:
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-038)
Fournisseur:
ProSci Inc.
Description:
Somatotropin(GH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4081P)
Fournisseur:
ProSci Inc.
Description:
BRSK1 peptide is used for blocking the activity of BRSK1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4085P)
Fournisseur:
ProSci Inc.
Description:
BRSK2 peptide is used for blocking the activity of BRSK2 antibody.
UOM:
1 * 50 µG
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