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Biosensis
Fournisseur:
Biosensis
Description:
The Neurotrophin Antibody Kit contains a collection of sheep antibodies raised against BDNF, NGF, NT3 and NT4/5. The kit is completed with one vial of normal sheep IgG for use as negative control. This kit presents a cost-effective way to investigate neurotrophin protein expression and function by immunological techniques such as immunohistochemistry, ELISA, and inhibition of biological activity.
Numéro de catalogue:
(BSENM-1778-50-B)
Fournisseur:
Biosensis
Description:
Nerve growth factor (NGF) is synthesized as a precursor (proNGF) which may be released and have physiological functions to cause cell death. It binds neurotrophin receptor p75 and sortilin and may also be important for the development of nervous system. proNGF is synthesized in target tissues and glia, transported retrogradely and may be released.
Biosensis' biotinylated proNGF antibody allowing more flexibility in experimental design by using the biotin-avidin/streptavidin detection method. The ability of biotinylated proNGF antibody to detect proNGF has been validated by WB.
UOM:
1 * 50 µG
Fournisseur:
Biosensis
Description:
The Biosensis CE Marked BDNF Rapid™ enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the preferential quantification of mature BDNF in less than 3 hours. This kit consists of a pre-coated mouse monoclonal anti-BDNF capture antibody, a biotinylated anti-BDNF detection antibody and horseradish peroxidase (HRP)-conjugated streptavidin. The addition of a substrate (3,3’,5,5’- tetramethylbenzidine, TMB) yields a coloured reaction product which is directly proportional to the concentration of BDNF present in samples and protein standards.
Numéro de catalogue:
(BSENG-1784-100)
Fournisseur:
Biosensis
Description:
Apolipoprotein E (ApoE) is a lipoprotein involved in fat metabolism and acts as cholesterol carrier between cells and across tissues. On a genetic level, three APOE alleles are described, APOE2, APOE3 and APOE4. These alleles give rise to six APOE isoforms, which are differentially implicated in various diseases. In the peripheral system, APOE4 is linked to increased risk of atherosclerosis. In the CNS, the ability of APOE4 in clearing beta-amyloid is impaired, while APOE3 and APOE2 are more efficient in performing this task. The APOE4 genotype in particular has been linked to increased risk for developing Alzheimer's Disease.
UOM:
1 * 1 EA
Numéro de catalogue:
(BSENC-1798-50)
Fournisseur:
Biosensis
Description:
Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Ref: uniprot.org. Antibody is specific for calbindin and does not recognize closely related proteins parvalbumin and calretinin as determined by Western Blotting.
UOM:
1 * 50 µl
Numéro de catalogue:
(BSENM-1813-100)
Fournisseur:
Biosensis
Description:
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. Ref: uniprot.org. Antibody is specific for parvalbumin and does not recognize closely related proteins calretinin and calbindin as determined by Western Blotting.
UOM:
1 * 1 EA
Numéro de catalogue:
(BSENM-1648-100)
Fournisseur:
Biosensis
Description:
Anti-DCX Mouse T4 Antibody [clone: 30]
UOM:
1 * 1 EA
Numéro de catalogue:
(BSENM-1656-100)
Fournisseur:
Biosensis
Description:
Anti-UBQL2 Mouse T4 Antibody [clone: 6H9]
UOM:
1 * 1 EA
Numéro de catalogue:
(BSENM-1725-100)
Fournisseur:
Biosensis
Description:
MAP1A and MAP1B are microtubule-associated protein which mediate the physical interactions between microtubules and components of the cytoskeleton (probably involved in autophagosome formation). MAP1A and MAP1B each consist of a heavy chain subunit and 3 different light chain subunits (LC1, LC2 and LC3). MAP1LC3A is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor form of MAP1LC3A is cleaved by APG4/ATG4B to form the cytosolic form LC3-1. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. MAP1LC3A is most abundant in heart, brain, liver, skeletal muscle and testis but is absent in thymus and peripheral leukocytes.
UOM:
1 * 1 EA
Numéro de catalogue:
(BSENR-1605-500)
Fournisseur:
Biosensis
Description:
Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).
UOM:
1 * 500 µG
Numéro de catalogue:
(BSENC-1557-100)
Fournisseur:
Biosensis
Description:
Dicer is the rate limiting enzyme in the formation of mature microRNAs.
UOM:
1 * 100 µl
Numéro de catalogue:
(BSENC-1393-50)
Fournisseur:
Biosensis
Description:
Neurofilaments are composed of three intermediate filament proteins: light (~68 kDa), medium (~160 kDa) and heavy (~200 kDa), which are involved in the maintenance of the neuronal caliber. Neurofilament medium runs on SDS-PAGE gels in the range 145-170 kDa, with some variation in different species.
UOM:
1 * 50 µl
Numéro de catalogue:
(BSENC-1538-100)
Fournisseur:
Biosensis
Description:
Peptide YY (PYY) is secreted from endocrine cells in the lower small intestine, colon and pancreas. PYY inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility (Ref: SWISS-Prot).
UOM:
1 * 100 µl
Numéro de catalogue:
(BSENC-1525-200)
Fournisseur:
Biosensis
Description:
Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) and upon binding to the receptor it induces the release of growth hormone from the pituitary. This ligand has an appetite-stimulating effect and is involved in growth regulation (Ref: SWISSPROT).
UOM:
1 * 200 µl
Numéro de catalogue:
(BSENC-1516-100)
Fournisseur:
Biosensis
Description:
Lysine acetylation of histones and non-histone proteins plays an important part in many cellular processes such as chromatin and nuclear signaling, transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication and repair.
UOM:
1 * 100 µl
Numéro de catalogue:
(BSENC-1540-100)
Fournisseur:
Biosensis
Description:
C-reactive protein has several roles associated with host defence such as; promoting agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. COFACTOR: Binds 2 calcium ions per subunit. C-reactive protein exists as a homopentamer. There are 2 alternatively spliced isoforms. C-reactive protein is found in plasma and its concentration increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 and IL-6.
UOM:
1 * 100 µl
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