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Numéro de catalogue:
(PRSI96-610)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI4423)
Fournisseur:
ProSci Inc.
Description:
ATG12 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5883)
Fournisseur:
ProSci Inc.
Description:
WDR92 Antibody: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR92, also known as monad, contains two WD40 repeats is widely expressed in human tissues, especially testis. Overexpression of this protein or its binding partner RNA polymerase II-associated protein 3 (RPAP3) potentiated apoptosis and caspase-3 activation induced by TNF-alpha and cycloheximide, suggesting that WDR92, together with RPAP3, may function as a novel modulator of apoptosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI25-479)
Fournisseur:
ProSci Inc.
Description:
ZNF510 may be involved in transcriptional regulation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-482)
Fournisseur:
ProSci Inc.
Description:
The function remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2323P)
Fournisseur:
ProSci Inc.
Description:
DAP kinase 2 peptide is used for blocking the activity of DAP kinase 2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2325P)
Fournisseur:
ProSci Inc.
Description:
Caspase-12 peptide is used for blocking the activity of caspase-12 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6535P)
Fournisseur:
ProSci Inc.
Description:
ECRG4 peptide is used for blocking the activity of ECRG4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI45-359)
Fournisseur:
ProSci Inc.
Description:
Anti-CAPZB Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-376)
Fournisseur:
ProSci Inc.
Description:
Anti-Cckar Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-355)
Fournisseur:
ProSci Inc.
Description:
Anti-CNR1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4697)
Fournisseur:
ProSci Inc.
Description:
LASS5 Antibody: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI26-164)
Fournisseur:
ProSci Inc.
Description:
AFG3L2 is a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. AFG3L2 gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-047)
Fournisseur:
ProSci Inc.
Description:
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-048)
Fournisseur:
ProSci Inc.
Description:
The exact function of PXT1 remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-044)
Fournisseur:
ProSci Inc.
Description:
TMEM146 is a single-pass type I membrane protein. The functions of TMEM146 remain unknown.
UOM:
1 * 50 µG
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