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Numéro de catalogue:
(PRSI25-024)
Fournisseur:
ProSci Inc.
Description:
SCMH1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6779P)
Fournisseur:
ProSci Inc.
Description:
YPEL5 peptide is used for blocking the activity of YPEL5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3051)
Fournisseur:
ProSci Inc.
Description:
OMI Antibody: Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication. Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases. The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs. Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs. Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI25-041)
Fournisseur:
ProSci Inc.
Description:
TRIM23 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-062)
Fournisseur:
ProSci Inc.
Description:
SIX3 belongs to the SIX/Sine oculis homeobox family. It contains 1 homeobox DNA-binding domain. SIX3 may be involved in visual system development.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-060)
Fournisseur:
ProSci Inc.
Description:
RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-233)
Fournisseur:
ProSci Inc.
Description:
SAC belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-230)
Fournisseur:
ProSci Inc.
Description:
ChGn transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). This protein is required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. It play an important role in chondroitin chain biosynthesis in cartilage.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-045)
Fournisseur:
ProSci Inc.
Description:
ZNF526 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 13 C2H2-type zinc fingers. ZNF526 may be involved in transcriptional regulation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4755)
Fournisseur:
ProSci Inc.
Description:
Stella Antibody: Stella was initially identified in primordial germ cells and pre-implantation embryos whose expression as a maternal factor is important in early embryonic development but is not required for germ cell specification in mice. In humans, Stella is thought to be a marker for pluripotency in embryonic stem (ES) cells as its expression is observed in primordial germ cells of both sexes and germ cell tumors but not in normal somatic tissues. However, in ES cell colonies, heterogeneous expression of Stella was seen in high throughput in situ hybridization assays, indicating that higher levels of complexity exist in otherwise thought to be undifferentiated ES cells. At least two distinct isoforms of Stella are known to exist.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5131P)
Fournisseur:
ProSci Inc.
Description:
TNFAIP3 peptide is used for blocking the activity of TNFAIP3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5115P)
Fournisseur:
ProSci Inc.
Description:
MATN4 peptide is used for blocking the activity of MATN4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6447)
Fournisseur:
ProSci Inc.
Description:
IFTLD1 Antibody: The intermediate filament tail domain-containing protein (IFLTD1) was initially identified as a candidate gene for pulmonary adenoma susceptibility 1 gene in mice. Transcripts of the gene were only detected in mouse lung tissue from strains carrying the Pas1-susceptible allele. Expression of different alleles of this gene in lung cancer cell lines resulted in different levels of colony formation in in vitro colony formation assays, suggesting that allelic variants of this gene can modulate growth of human cancer cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6871P)
Fournisseur:
ProSci Inc.
Description:
FCHO2 peptide is used for blocking the activity of FCHO2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6383)
Fournisseur:
ProSci Inc.
Description:
TEKT5 Antibody: Tektins are insoluble alpha-helical proteins related to intermediate filament proteins and are essential for the assembly of cilia and flagella. Tektin-5 (TEKT5) is a recently identified member of the Tektin family. It is predominantly expressed in testis, and its expression is upregulated during testis development. It is present in sperm flagella but not in heads, suggesting that it may act as a middle component required for flagellar stability and sperm mobility.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6393)
Fournisseur:
ProSci Inc.
Description:
AP3M1 Antibody: The AP3 complex is a heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3M1 is highly homologous to AP3M2 but is the preferred binding partner to the YQRL motif from the cytosolic domain of TGN38. AP3M1 has also been shown to interact with the HIV-1 virulence protein Nef.
UOM:
1 * 1 EA
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