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ProSci Inc.
Numéro de catalogue:
(PRSI92-707)
Fournisseur:
ProSci Inc.
Description:
Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumour cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognises class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-565)
Fournisseur:
ProSci Inc.
Description:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-560)
Fournisseur:
ProSci Inc.
Description:
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-571)
Fournisseur:
ProSci Inc.
Description:
The production of the second messenger molecules diacylglycerol. (DAG) and inositol 1, 4, 5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXG-6106)
Fournisseur:
ProSci Inc.
Description:
Anti-NTF4 Chicken Polyclonal Antibody
UOM:
1 * 500 µG
Numéro de catalogue:
(PRSI46-353)
Fournisseur:
ProSci Inc.
Description:
Anti-SEPT3 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-339)
Fournisseur:
ProSci Inc.
Description:
Anti-SECISBP2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-978)
Fournisseur:
ProSci Inc.
Description:
Anti-GRM7 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-356)
Fournisseur:
ProSci Inc.
Description:
Anti-HTR2C Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-346)
Fournisseur:
ProSci Inc.
Description:
Anti-SEL1L Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI48-680)
Fournisseur:
ProSci Inc.
Description:
Rif1 (also known as telomere-associated protein RIF1 and Rap1-interacting factor 1) is a mouse ortholog of the yeast Rif1 family of telomere-associated proteins identified on the basis of its high expression in primordial germ cells and embryo-derived pluripotent stem cell lines. Mouse Rif1 is a protein involved in negative regulation of telomere length. It is also localized to ATM dependent DNA damage foci and may act at the chromatin level to allow access to some factors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI30-216)
Fournisseur:
ProSci Inc.
Description:
ZMPSTE24 is a member of the peptidase M48A family. This protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in ZMPSTE24 gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.The protein encoded by this gene is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3285)
Fournisseur:
ProSci Inc.
Description:
TLR11 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3305)
Fournisseur:
ProSci Inc.
Description:
ARMER Antibody: Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3299)
Fournisseur:
ProSci Inc.
Description:
TIRP Antibody: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappa B. Expression of TIRP appears to be essential for TLR4 signalling.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-239)
Fournisseur:
ProSci Inc.
Description:
Anti-KCNN2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
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