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ProSci Inc.
Numéro de catalogue:
(PRSI35-484)
Fournisseur:
ProSci Inc.
Description:
Anti-Influenza Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate))
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4331)
Fournisseur:
ProSci Inc.
Description:
BRCC36 Antibody: Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of BRCC36 are known to exist.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4339)
Fournisseur:
ProSci Inc.
Description:
TEM7 Antibody: Tumor endothelial marker 7 (TEM7) was identified through serial analysis of gene expression on endothelial cells isolated from human normal and malignant colorectal tissues. Further experiments verified TEM7 was highly expressed in the endothelium of numerous other cancer types including breast, lung and brain tumors. At least four isoforms of TEM7 are known to exist; these include intracellular, secreted, and membrane-bound forms. A homologous protein, TEM7R (also known as PLXDC2), acts as a binding partner to TEM7 and is also abundantly expressed in the endothelium of malignant colorectal cancer but is absent or rare in normal colon mucosa. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI26-773)
Fournisseur:
ProSci Inc.
Description:
The exact function of SAMD14 remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4657P)
Fournisseur:
ProSci Inc.
Description:
EVER2 peptide is used for blocking the activity of EVER2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI46-854)
Fournisseur:
ProSci Inc.
Description:
Anti-GRIK3 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXP-5257BT)
Fournisseur:
ProSci Inc.
Description:
RANTES is a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. It binds to CCR1, CCR3, CCR4 and CCR5 and is one of the major HIV suppressive factors produced by CD8+ T cells. Recombinant RANTES protein induces a dose dependent inhibition of different strains of HIV 1, HIV 2, and simian immunodeficiency virus (SIV). It is T cell and macrophage specific, induced by mitogens, and belongs to the intercrine beta (chemokine CC) family.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI46-861)
Fournisseur:
ProSci Inc.
Description:
Anti-LPO Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-600)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
UOM:
1 * 25 µG
Numéro de catalogue:
(PRSI96-625)
Fournisseur:
ProSci Inc.
Description:
Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
UOM:
1 * 20 µG
Numéro de catalogue:
(PRSI7033P)
Fournisseur:
ProSci Inc.
Description:
SGSM1 peptide is used for blocking the activity of SGSM1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI29-076)
Fournisseur:
ProSci Inc.
Description:
The function of the ZNF70 has not yet been determined
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-062)
Fournisseur:
ProSci Inc.
Description:
NR2F2, an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, NR2F2 stimulates transcription directly. NR2F2, MyoD and p300 interact in a competitive manner, and that increasing amounts of NR2F2 have the ability to reduce the interaction between myoD and p300 invitro. NR2F2 post-transcriptionally regulates myoD activity/function, and that crosstalk between orphan nuclear receptors and the myogenic bHLH proteins has functional consequences for differentiation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-065)
Fournisseur:
ProSci Inc.
Description:
DEAF1 down-regulates transcription of those genes by binding to sequence with multiple copies of TTC[CG]G present in their own promoter and that of the HNRPA2B1 gene. DEAF1 binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. DEAF1 activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI29-067)
Fournisseur:
ProSci Inc.
Description:
ZNF253 may function as a transcription factor. Seem to have a transcriptional repression activity
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6631)
Fournisseur:
ProSci Inc.
Description:
EPAC1 Antibody: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
UOM:
1 * 1 EA
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