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STEMCELL Technologies
Numéro de catalogue:
(STMC100-0307)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1, antibody against human, chimpanzee CD4, unconjugated.
UOM:
1 * 1 EA
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Numéro de catalogue:
(STMC100-0173)
Fournisseur:
STEMCELL Technologies
Description:
Supplement for hematopoietic differentiation optimised for lymphoid potential.
UOM:
1 * 7 mL
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Numéro de catalogue:
(STMC100-0172)
Fournisseur:
STEMCELL Technologies
Description:
Supplement for mesoderm specification with downstream lymphoid potential.
UOM:
1 * 265 µl
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Numéro de catalogue:
(STMC05978)
Fournisseur:
STEMCELL Technologies
Description:
Defined medium for naïve-like human pluripotent stem cells.
UOM:
1 * 1 Kit
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Fournisseur:
STEMCELL Technologies
Description:
Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma <i>et al.</i>). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau <i>et al.</i>). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).
Numéro de catalogue:
(STMC17655)
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic positive selection of particle-free mouse cells labelled with biotinylated antibodies.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC78111.1)
Fournisseur:
STEMCELL Technologies
Description:
Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) subclass of the transforming growth factor beta (TGF-β) superfamily. It binds a receptor complex comprising BMPR1B and BMPR2, which then activates the SMAD signaling pathway (Carreira <i>et al.</i>; Nishitoh <i>et al.</i>; Osório <i>et al.</i>). GDF-5 enhances chondrogenic differentiation of mesenchymal stem cells, skeletogenesis, and dendrite growth during development (Coleman <i>et al.</i>; Francis-West <i>et al.</i>). Studies in rat demonstrated that GDF-5 regulates patterning, neurogenesis, astrogliogenesis, and neuronal specification (Gajavelli <i>et al.</i>; Krieglstein <i>et al.</i>; O’Keeffe <i>et al.</i>).
UOM:
1 * 1 EA
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Fournisseur:
STEMCELL Technologies
Description:
Interleukin 3 (IL-3) is a species-specific pleiotropic cytokine that promotes the survival and proliferation of pluripotent hematopoietic stem cells and lineage-committed progenitor cells and their differentiation into mature cells of most lineages, including basophils, neutrophils, eosinophils, macrophages, dendritic cells, erythrocytes, and megakaryocytes (Yang <i>et al.</i>; Dorssers <i>et al.</i>; Broughton <i>et al.</i>). IL-3 is produced by activated T cells and has a physiological role in inflammation and allergies by promoting the secretion of inflammatory mediators such as histamine, IL-4, and IL-6 by basophils and eosinophils (Broughton <i>et al.</i>). The IL-3 receptor consists of a unique alpha subunit (CD123) and a beta common subunit (βc or CD131) that is shared with the receptors for IL-5 and GM-CSF, and is the principal signal transduction subunit for these cytokines. IL-3 binding to the heterodimeric receptor activates JAK/STAT, MAPK, and PI3K signaling pathways (Woodcock <i>et al.</i>).
Numéro de catalogue:
(STMC05020)
Fournisseur:
STEMCELL Technologies
Description:
Medium for long-term maintenance of human PSC-derived cardiomyocytes.
UOM:
1 * 1 KIT
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Fournisseur:
STEMCELL Technologies
Description:
CD40 ligand is a type II transmembrane glycoprotein that belongs to the tumor necrosis factor (TNF) superfamily (Quezada <i>et al.</i>). CD40 ligand forms a bioactive homotrimer that exists as both soluble and membrane-bound forms (Khandekar <i>et al.</i>). CD40 ligand is expressed on T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. Its receptor, CD40, is expressed on B cells, dendritic cells, macrophages, monocytes, platelets, endothelial cells, and epithelial cells (van Kooten and Banchereau). Binding of CD40 ligand to CD40 stimulates B cell proliferation, immunoglobulin class switching, antibody secretion, and T cell-dependent humoral responses. Dysregulation of CD40 ligand contributes to immune deficiency in HIV and AIDS (Rickert <i>et al.</i>). CD40 ligand has also been linked to the pathology of atherosclerosis, atherothrombosis, and restenosis (Hassan <i>et al.</i>).
Numéro de catalogue:
(STMC05876)
Fournisseur:
STEMCELL Technologies
Description:
Defined, feeder-free maintenance medium for human ES and iPS cells.
UOM:
1 * 1 Kit
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Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 10 (FGF-10) is a member of the fibroblast growth factor (FGF) family which is predominantly expressed by mesenchymal fibroblasts during embryonic development (Emoto <i>et al.</i>; Igarashi <i>et al.</i>). It binds with high affinity to fibroblast growth factor receptor 2-IIIb (FGFR2-IIIb), and also has a weaker affinity for FGFR1-IIIb (Beer <i>et al.</i>). FGF-10 and FGF-7 have similar receptor binding properties and target cell specificities but are differentially regulated by components of the extracellular matrix (Emoto <i>et al.</i>; Igarashi <i>et al.</i>). FGF-10 has been shown to mediate epithelial-mesenchymal interactions, which are essential to lung development (Sekine <i>et al.</i>; Ware and Matthay). FGF-10 also has a role in mobilisation and proliferation of lung-resident mesenchymal stem cells (MSCs) and protection and repair against acute lung injury (Tong <i>et al.</i>; Ware and Matthay) and endodermal differentiation of human pluripotent stem cells to insulin-producing pancreatic-like cells (Takeuchi <i>et al.</i>). This product is animal component-free.
Numéro de catalogue:
(STMC78184.1)
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 6 (FGF-6) is a heparin-binding member of the FGF family, regulators of cell proliferation, differentiation, and function. FGF-6 binds and signals through the FGF receptors 1c, 2c, and 4 (Ornitz <i>et al.</i>). FGF-6 is a potent mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells (Asada <i>et al.</i>; Pizette <i>et al.</i>; Ropiquet <i>et al.</i>). FGF-6 is primarily expressed in epithelial and mesenchymal cell lineages. During development, FGF-6 is expressed in skeletal muscle, consistent with its role in muscle differentiation and regeneration (Floss <i>et al.</i>). FGF-6 has also been shown to promote chondrogenesis in embryonic somites in conjunction with transforming growth factor beta 2 (TGF-β2; Grass <i>et al.</i>).
UOM:
1 * 1 EA
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Numéro de catalogue:
(STMC100-1602)
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal antibody against mouse, hamster CD4, APC-conjugated.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1601)
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal antibody against mouse, hamster CD4, unconjugated.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1456)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal antibody against human perforin, PE-conjugated.
UOM:
1 * 1 EA
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
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