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Protéines et Peptides
Numéro de catalogue:
(PRSI91-390)
Fournisseur:
ProSci Inc.
Description:
Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 has high expression in kidney, brain, and cerebellum, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected in lung, pancreas, gastric mucosa and cytotrophoblasts. As a classic cadherin, Cadherin-6 will form homodimers and promote intercellular adhesion with itself and, possibly, Cadherin-9 and -14.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-424)
Fournisseur:
ProSci Inc.
Description:
BTLA is a type I transmembrane glycoprotein of the CD28 family of T cell costimulatory molecules. BTLA functions as a coinhibitor on activated T cells and on B cells and dendritic cells. The extracellular domain (ECD) of this Ig superfamily protein contains one V-type Ig-like domain, which interacts with HVEM.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-008)
Fournisseur:
ProSci Inc.
Description:
Calcineurin Subunit B Type 1 belongs to the calcineurin regulatory subunit family. Calcineurin Subunit B Type 1 is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase. It is composed of a catalytic subunit (A) and a regulatory subunit (B). It contains four EF-hand domains and four functional calcium-binding sites. Calcineurin Subunit B Type 1 plays an improtant role in the T cell activation pathway.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-470)
Fournisseur:
ProSci Inc.
Description:
Ephrin Type-A Receptor 7 (EPHA7) is a single-pass type I membrane protein which belongs to the Eph family of transmembrane receptor tyrosine kinases. It contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile alpha motif) domain. EPHA7 is a receptor for members of the ephrin-A family. Eph receptors are largely expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. EPHA7 functions as a repulsive guidance molecule during the targeting of retinal axons to the superior colliculus and of neocortical axons to the thalamus. EPHA7 is expressed at a substantial level in most human lung cancers. The high expression of EPHA7 protein may participate in the malignancy transformation, invasion progression and metastasis of primary hepatocellular carcinoma. EPHA7 may involve in smoking related lung carcinogenesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-648)
Fournisseur:
ProSci Inc.
Description:
Follistatin-like 1 (FSTL1) is a secreted glycoprotein that has been grouped into the follistatin family of proteins. FSTL1 is composed of a follistatin domain and two non-functional calcium-binding motifs. It was originally cloned as a TGF beta 1 inducible factor but subsequently shown to regulate diverse developmental pathways and tissue homeostasis. Ablation of the FSTL1 gene in the mouse results in several structural developmental defects and neonatal lethality due to respiratory failure. FSTL1 suppresses BMP signalling, but the precise mechanism of its action has not been elucidated. FSTL1 is expressed in the human placenta, mainly in extra villous trophoblasts.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-560)
Fournisseur:
ProSci Inc.
Description:
Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-011)
Fournisseur:
ProSci Inc.
Description:
Recombinant Human Interleukin-2 is a highly purified protein with a molecular weight of approximately 15,300 Daltons. The chemical name is des-alanyl-1, serine-125 Human Interleukin-2. It is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the Human IL-2 gene, and the resulting expression clone encodes a modified Human IL-2. This recombinant form differs from native Interleukin-2 in following ways: 1) it is not glycosylated; 2) the molecule has no N-terminal alanine; 3) the molecule has serine substituted for cysteine at amino acid position 125; 4) the aggregation state of molecule is likely to be different from that of native IL-2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-022)
Fournisseur:
ProSci Inc.
Description:
Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-251)
Fournisseur:
ProSci Inc.
Description:
Zinc finger and BTB domain-containing protein 9 is a protein-coding gene. ZBTB9 is a 473 amino acids protein that Contains 1 BTB (POZ) domain and 2 C2H2-type zinc fingers. Diseases associated with ZBTB9 include systemic lupus erythematosus, and lupus erythematosus. Zinc finger and BTB domain-containing protein 9 may be involved in transcriptional regulation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-723)
Fournisseur:
ProSci Inc.
Description:
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-228)
Fournisseur:
ProSci Inc.
Description:
UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognised as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. UBA5 is located primarily in cytoplasm, while it generally localises to the nucleus in presence of SUMO2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6213P)
Fournisseur:
ProSci Inc.
Description:
Bcl9L peptide is used for blocking the activity of Bcl9L antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6215P)
Fournisseur:
ProSci Inc.
Description:
CTTNBL1 peptide is used for blocking the activity of CTNNBL1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6423P)
Fournisseur:
ProSci Inc.
Description:
KCNK13 peptide is used for blocking the activity of KCNK13 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4739P)
Fournisseur:
ProSci Inc.
Description:
18 amino acid peptide near the amino terminus of human BMP15.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6599P)
Fournisseur:
ProSci Inc.
Description:
LEMD1 peptide is used for blocking the activity of LEMD1 antibody.
UOM:
1 * 50 µG
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