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Protéines et Peptides
Fournisseur:
ENZO LIFE SCIENCES
Description:
HDAC Substrate (fluorogenic)
Fournisseur:
ENZO LIFE SCIENCES
Description:
CaM kinase II inhibitor
Numéro de catalogue:
(ENZOBMLP8010005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Substrate for ubiquitin C-terminal hydrolases (UCHs)
UOM:
1 * 5 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inhibitor of PP1 and PP2A
Fournisseur:
ENZO LIFE SCIENCES
Description:
Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-ß-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 ß-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.
Numéro de catalogue:
(PRSI92-123)
Fournisseur:
ProSci Inc.
Description:
Complement Component 1Q Subcomponent-Binding Protein (C1QBP) is a nucleus protein that belongs to the MAM33 family. C1QBP is known to bind to the globular heads of C1q molecules and inhibit C1 activation. Mitochondrial C1QBP is a critical mediator of p14ARF-induced apoptosis. C1QBP functions as a chemotactic factor for immature dendritic cells, and migration is mediated through ligation of both C1QBP and cC1qR/CR. C1QBP overexpression successfully blocks mRNA accumulation from the adenovirus major late transcription unit (MLTU) and stimulates RNA polymerase II carboxy-terminal domain phosphorylation in virus-infected cells.
UOM:
1 * 0,05 mg
New Product
Numéro de catalogue:
(ENZOBMLG5150001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
G protein antagonist
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(PRSI96-326)
Fournisseur:
ProSci Inc.
Description:
Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI96-089)
Fournisseur:
ProSci Inc.
Description:
CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The extracellular domain has the cysteinerich repeat regions, which are characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules,which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by an inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(ENZOALX260023M001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Substrate for caspase-1 and -4
UOM:
1 * 1 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Caspase-3 inhibitor
Numéro de catalogue:
(ENZOALX260017M001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cathepsin B inhibitor
UOM:
1 * 1 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Caspase substrate
Numéro de catalogue:
(ENZOALX630108C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inactivation with formaldehyde leads to non-toxic form of tetanus toxin.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX630100C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cytotoxic and enterotoxic
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOBMLPW87200050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
High integrity preparation for use in proteasome research.
UOM:
1 * 50 µG
New Product
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