Print…- Startpagina > Antilichamen
U heeft gezocht op:
511 493 Er zijn resultaten gevonden.
Antilichamen
Itemnummer:
(ENZOALX210889R100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Host: Rabbit
UOM:
1 * 100 µl
New Product
Itemnummer:
(NOVUNBP2-34287-0.1)
Leverancier:
Novus Biologicals
Omschrijving:
CD45, also known as leukocyte common antigen (LCA), T200, or Ly5, is a member C of the class 1 receptor-like protein tyrosine phosphatase (PTPRC) family (1, 2). It is a transmembrane glycoprotein which, due to alternative splicing, has a multiple isoforms with a theoretical molecular weight ranging from 180 - 220 kDa (1, 3-5). Human CD45 is synthesized as a 1281 amino acid sequence consisting of an alternatively spliced extracellular receptor-like region, a cysteine-rich domain, fibronectin-like III repeats, a transmembrane segment, and a cytoplasmic region with tandem protein tyrosine phosphatase (PTP) domains: the membrane proximal domain (D1) and the membrane distal domain (D2) (3, 5). CD45 is expressed on all nucleated hematopoietic cells and their precursors, except mature red blood cells, and is one of the most abundantly-expressed cell-surface glycoproteins, comprising approximately 10% of surface proteins in lymphocytes (3). Functionally, CD45 is essential for development and activation of T-cells and B-cells (1-5). More specifically, CD45 positively regulates antigen receptor signaling and Src-family member kinase activity (1, 3). There are many ways to regulate CD45 phosphatase activity including ligand binding, dimerization, protein interactions, cellular localization, and covalent modifications (3, 6). Ligands for CD45 include pUL11, a transmembrane protein of the cytomegalovirus RL11 (CMV RL11) family, and placental protein 14 (PP14), both of which exclusively bind CD45, and various lectins including CD22, galectin-1, galectin-3, macrophage mannose receptor (MR), and macrophage galactose-type lectin (MGL) (6).
Given its role in immune cell development and activation, CD45 has also been linked to a variety of diseases. The importance of CD45 in immunity has been revealed in human and mouse studies where CD45-deficiency leads to a severe-combined immunodeficiency (SCID) phenotype (2, 3, 6). A CD45-knockout mice study revealed inhibited thymocyte production and poor B-cell response, whereas CD45 activation in mice causes lymphoproliferation and autoantibody production (3). CD45 variants have been associated with altered immune function and autoimmune disorders including multiple sclerosis, systemic lupus erythematosus (SLE), and rheumatoid arthritis (6). Furthermore, altered CD45 expression has been implicated in oncological conditions including chronic lymphatic leukemia, acute lymphatic leukemia, Hodgkin lymphoma, multiple myeloma, and diffuse large B-cell lymphoma (6). Considering its role in autoimmune disorders, immunodeficiency and cancer, CD45 is an ideal therapeutic target (3, 6). The main approaches to control CD45 function is through either selective inhibitors or anti-CD45 antibodies (3). Alternative names for CD45 includes B220, CD antigen: CD45, CD45 antigen, CD45R, EC 3.1.3.48, GP180, LCA, Leukocyte common antigen, LY5, protein tyrosine phosphatase receptor type c polypeptide, PTPRC, receptor-type tyrosine-protein phosphatase C, T200 Glycoprotein, and T200. References 1. Trowbridge, I. S., & Thomas, M. L. (1994). CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annual review of immunology. https://doi.org/10.1146/annurev.iy.12.040194.000505 2. Andersen, J. N., Jansen, P. G., Echwald, S. M., Mortensen, O. H., Fukada, T., Del Vecchio, R., Tonks, N. K., & Moller, N. P. (2004). A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 3. Hermiston, M. L., Xu, Z., & Weiss, A. (2003). CD45: a critical regulator of signaling thresholds in immune cells. Annual review of immunology. https://doi.org/10.1146/annurev.immunol.21.120601.140946 4. Tonks, N. K., Diltz, C. D., & Fischer, E. H. (1990). CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity. The Journal of biological chemistry. 5. Nam, H. J., Poy, F., Saito, H., & Frederick, C. A. (2005). Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45. The Journal of experimental medicine. https://doi.org/10.1084/jem.20041890 6. Rheinlander, A., Schraven, B., & Bommhardt, U. (2018). CD45 in human physiology and clinical medicine. Immunology letters. https://doi.org/10.1016/j.imlet.2018.01.009
UOM:
1 * 0,1 mg
Leverancier:
Biotium
Omschrijving:
CD3e (Clone SK7) is a mouse monoclonal antibody derived from the extracellular domain of the CD3 epsilon chain. This antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance. The antibody is available conjugated to either a CF® Dye or Astral™ tandem dye. They are supplied in PBS, 0,1% BSA, 0,05% azide.
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
rSec6 and rSec8 are rat homologs of the yeast Sec6 and Sec8 proteins that are essential for protein transport between the Golgi apparatus and the plasma membrane. In yeast, Sec8 is part of a 19.5S complex that includes Sec6 and Sec15, that also associate with the ras-like GTP binding protein Sec4. An analogous 17S complex in rat brain was found to contain rSec6 and rSec8, along with eight proteins with a combined molecular weight of 743 kDa. The membrane-associated rSec6/8 complex co-immunoprecipitates with syntaxin, providing evidence that this complex is involved in synaptic vesicle docking and fusion at the presynaptic terminal.
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Hsp70-Hsp90 Organizing Protein (HOP, p60) is an ~60kDa protein that is a critical intermediate component for the efficient maturation of steroid receptor complexes, serving to recruit Hsp90 to Hsp70-containing complexes. HOP contains three tetratricopeptide repeat (TPR) domains, TPR1, TPR2a, and TPR2b.
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
GC UNC45 (general cell UNC45/unc45a) is an Hsp90 co-chaperone that has been shown to play a critical role in the chaperoning of myosin proteins as well as the progesterone receptor (PR). There are two known vertebrate isoforms of UNC45 that are functional orthologs of the C. elegans unc-45, an important protein in the development of organized body wall muscles. The vertebrate general cell form (GC UNC45/unc45a) is ubiquitously expressed, while the striated muscle-specific isoform (SM UNC45/unc45b) is found in cardiac and skeletal muscle. In vitro, GC UNC45 preferentially binds the Hsp90 beta isoform, and is specifically required for proper cellular distribution of Hsp90β but not Hsp90α.
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Synaptotagmins (Syt) are membrane-trafficking proteins characterized by an N-terminal transmembrane region, a variable linker, and two C-terminal C2-domains, C2A and C2B. At least twelve Synaptotagamins are expressed in vertebrates and can be found in both vesicular and plasma membranes.
Itemnummer:
(PRSI10-997)
Leverancier:
ProSci Inc.
Omschrijving:
Anti-PF-06801591 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Itemnummer:
(PRSI11-008)
Leverancier:
ProSci Inc.
Omschrijving:
Anti-AMG-301 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Itemnummer:
(PRSI10-987)
Leverancier:
ProSci Inc.
Omschrijving:
Anti-BCD-145 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Itemnummer:
(PRSI10-979)
Leverancier:
ProSci Inc.
Omschrijving:
Anti-GZ-402668 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Itemnummer:
(PRSI10-981)
Leverancier:
ProSci Inc.
Omschrijving:
Anti-MEDI3902 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Itemnummer:
(ENZOBPDABS012241)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Exendin-4 is a 39-amino-acid peptide found in venom from the Gila monster Heloderma suspectum. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. Exendin-4 is a potent agonist of the GLP-1 receptor and hence a potent stimulator of insulin secretion.
UOM:
1 * 1 mg
New Product
Itemnummer:
(ENZOENZABS2340100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Recommended Applications: Flow Cytometry, IF
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Itemnummer:
(ENZOADI905746100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
The actions of the octapeptide circulatory hormone angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane domain-containing GPCR family. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II in cardiovascular homeostasis. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing.
UOM:
1 * 1 EA
New Product
Itemnummer:
(ENZOADI905811100)
Leverancier:
ENZO LIFE SCIENCES
Omschrijving:
Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven-transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1) receptors regulate vasoconstriction, and are expressed in vascular smooth muscle, kidney, myometrium, bladder, adipocytes, hepatocytes, platelets and testis; V1b (V3) receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus; and V2 receptors of the kidney regulate the antidiuretic effects of AVP. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas.
UOM:
1 * 1 EA
New Product
Bel voor prijs
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
Bijkomende documentatie kan noodzakelijk zijn voor dit item. Een VWR-verantwoordelijke zal contact opnemen met u indien nodig.
Producten die gemarkeerd zijn met dit symbool werden geblokkeerd door uw organisatie. Gelieve contact op te nemen met uw aankoopafdeling
Het originele artikel is niet langer beschikbaar. Het getoonde alternatief is wel beschikbaar.
Product(en) met dit symbool worden binnenkort niet meer verkocht - verkoop tot het einde voorraad. Alternatieven zijn mogelijk beschikbaar door te zoeken met het VWR artikelnummer dat hierboven wordt vermeld. Neem voor meer informatie contact op met onze Customer Service op 016 385 011.
|
|||||||||
Lijst
