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Antilichamen
Itemnummer:
(BOSSBS-5238R-CY5.5)
Leverancier:
Bioss
Omschrijving:
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-5238R-FITC)
Leverancier:
Bioss
Omschrijving:
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-9678R-A488)
Leverancier:
Bioss
Omschrijving:
C19orf21 is a 679 amino acid protein that is encoded by a gene located on human chromosome 19. Chromosome 19 consists of approximately 63 million bases and makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fcα receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0265R-A750)
Leverancier:
Bioss
Omschrijving:
CKLFSF2 isoform 1.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-3805R-A680)
Leverancier:
Bioss
Omschrijving:
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-7753R-A350)
Leverancier:
Bioss
Omschrijving:
KLHL9 is the substrate-specific adapter for a CUL3-based E3 ubiquitin-protein ligase complex. Within this complex, KLHL9 controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-3806R-A350)
Leverancier:
Bioss
Omschrijving:
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-3018R-CY5.5)
Leverancier:
Bioss
Omschrijving:
Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-3018R-CY5)
Leverancier:
Bioss
Omschrijving:
Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-1420R-A350)
Leverancier:
Bioss
Omschrijving:
NCoR2_Nuclear receptor corepressor 2_mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-4537R-A750)
Leverancier:
Bioss
Omschrijving:
Streptococcus suis suilysin belongs to a family of thiol-activated, membrane damaging toxins produced by some gram-positive bacteria. Although suilysin has been implicated as virulence associated, it has yet to be shown conclusively to be a virulence factor.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8217R-A350)
Leverancier:
Bioss
Omschrijving:
FAM59B
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8216R-HRP)
Leverancier:
Bioss
Omschrijving:
Isoform 1 and isoform 3 are widely expressed with highest levels in retina and testis, with isoform 1 being the mot abundant in all tissues tested.Involvement in disease:Defects in FAM161A are the cause of retinitis pigmentosa type 28 (RP28) . A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-11267R-CY7)
Leverancier:
Bioss
Omschrijving:
CCT2 is one of eight largely unrelated subunit proteins found in a protein chaperone complex known as the chaperonin-containing TCP-1 (CCT) or TRiC complex. The CCT complex is an abundanct cytoslic component that is credited with helping newly synthesized polypeptides adopt the correct conformation (1). Proteins that fold and assemble with the help of CCT include the cytoskeletal proteins actin and tubulin as well as up to 15% of newly synthesized eukaryotic proteins (2). CCT2 is the β-subunit of the chaperone complex and is one of several CCT proteins that exhibit increased expression in response to stress. This implies that the CCT complex helps cells recover from protein damage by assisting in protein folding and assembly (3). CCT subunit levels also change throughout the cell cycle, with lower proteins levels (and reduced chaperone activity) found during induced cell cycle arrest during at M phase (4). Each CCT subunit is thought to perform a specific function during protein folding and assembly (5); CCT2 exhibits both actin and tubulin binding activities (6,3) but the exact molecular function on this subunit remains uncertain.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8217R-HRP)
Leverancier:
Bioss
Omschrijving:
FAM59B
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-1173R-A647)
Leverancier:
Bioss
Omschrijving:
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).
UOM:
1 * 100 µl
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
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