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Antilichamen
Itemnummer:
(BOSSBS-13611R-A350)
Leverancier:
Bioss
Omschrijving:
Sox-30 encodes a member of the Sox (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Sox-30 is expressed in testis and may act as a transcriptional regulator after forming a protein complex with other proteins. Sox-30 may be involved in the differentiation of developing male germ cells. Two transcript variants encoding distinct isoforms have been identified for the human Sox-30 gene. Sox family transcription factors influence cell differentiation, development and sex determination. Sox-30 contains a unique DNA binding domain, known as the high mobility group (HMG) box, that is related to that of the testis determining gene, SRY. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. Several Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0668R-A488)
Leverancier:
Bioss
Omschrijving:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-13610R-A750)
Leverancier:
Bioss
Omschrijving:
May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0668R-A350)
Leverancier:
Bioss
Omschrijving:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-2270R-A750)
Leverancier:
Bioss
Omschrijving:
p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins. Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0337R-A680)
Leverancier:
Bioss
Omschrijving:
Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-2168R-CY5.5)
Leverancier:
Bioss
Omschrijving:
ADAR1 converts adenosine to inosine in dsRNA, which destabilizes the dsRNA helix. This activity is important for various functions like site-specific RNA editing of transcripts of the glutamate receptors and modifying viral RNA genomes (which may be responsible for hypermutation of certain negative-stranded viruses, e.g., measles virus). ADAR1 also binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. This protein is ubiquitously expressed, with the highest levels being found in brain and lung.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0338R-A350)
Leverancier:
Bioss
Omschrijving:
Hepatitis G virus is from a group of viruses called GB viruses (GB virus A, GB virus B and GB virus C) and is also designated as GB virus C (GBV C). HGV is a positive stranded RNA virus, with a genome of 10 KB and appears, on the basis of genome length and organisation, to be a member of the Flaviviridae and distinct from the hepatitis C virus (HCV). HGV infection appears to be transmitted following receipt of blood from HGV RNA positive donors, however, these patients have only moderate liver enzyme elevations and do not develop chronic liver disease.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-13322R-A647)
Leverancier:
Bioss
Omschrijving:
Glycosylation of asparagine residues in Asn-X-Ser/Thr motifs in proteins commonly occur in the lumen of the endoplasmic reticulum (ER). Glucosidase I catalyzes the first step in the N-linked oligosaccharide processing pathway. It specifically removes the distal alpha 1,2-linked glucose residue from the Glc3-Man9-GlcNAc2 oligosaccharide precursor. Glucosidase I contains a short cytosolic tail, a single pass transmembrane domain and a large C-terminal catalytic domain located on the luminal side of the ER. Mutations in the gene encoding Glucosidase I result in the congenital disorder glycosylation (CDG-IIb), which is characterized by generalized hypotonia, dysmorphic features, hepatomegaly, hypoventilation, feeding problems, seizures and death. Two point mutations in the Glucosidase I gene have been identified and result in amino acid substitutions, namely Arg486Thr and Phe652Leu, that affect polypeptide folding and active site formation.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-12213R-CY3)
Leverancier:
Bioss
Omschrijving:
The transcpritional repressor ZBRK1, also designated zinc finger and BRCA1-interacting protein with a KRAB domain 1 or zinc finger protein 350, belongs to the Krüppel C2H2-type zinc-finger protein family of proteins. ZBRK1 localizes mainly to the nucleus and may be associated with the nuclear matrix. It is a widely expressed protein that binds to BRCA1. ZBRK1 plays an important role in transcriptional regulation. Likely targets of gene regulation are DNA damage response genes, which effect the survival and growth control of cells. ZBRK1 contains an N-terminal KRAB domain, a C-terminal BRCA1-binding region and eight central zinc-fingers.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-9851R-A680)
Leverancier:
Bioss
Omschrijving:
The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron (SMN) protein, and is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalysed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 (also designated Jak-binding protein 1, JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG) domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved, ubiquitously expressed protein that localizes primarily to the cytoplasm, and may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-5394R-A555)
Leverancier:
Bioss
Omschrijving:
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-9443R-A680)
Leverancier:
Bioss
Omschrijving:
Voltage-gated K+ channels in the plasma membrane control the repolarisation and the frequency of action potentials in neurons, muscles, and other excitable cells. Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-9851R-A750)
Leverancier:
Bioss
Omschrijving:
The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron (SMN) protein, and is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalysed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 (also designated Jak-binding protein 1, JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG) domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved, ubiquitously expressed protein that localizes primarily to the cytoplasm, and may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0094R-HRP)
Leverancier:
Bioss
Omschrijving:
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-0094R-A680)
Leverancier:
Bioss
Omschrijving:
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
UOM:
1 * 100 µl
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
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