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Antilichamen
Itemnummer:
(BOSSBS-2139R)
Leverancier:
Bioss
Omschrijving:
L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-13529R)
Leverancier:
Bioss
Omschrijving:
G protein-coupled receptor 3 (GPR3), also designated ACCA orphan receptor, is a 330 amino acid member of the G protein-coupled receptor 1 family. The function of GPR3 is mediated by G proteins which activate adenylate cyclase. GPR3 is a mutli-pass membrane protein that is located on the cellular membrane of cells and is detected at low levels in the eye, kidney, lung, ovary and testis. GPR3 is most highly expressed in the central nervous system, where it stimulates the production of cAMP, leading to neurite outgrowth and myelin inhibition. In oocytes, this control over cAMP production can halt meiosis and prevent progesterone-induced meiotic maturation. Mice deficient for GPR3 are able to reproduce but have no control over the oocyte maturation process, which results in nondeveloping early embryos and fragmented oocytes as the mice age.
UOM:
1 * 100 µl
Leverancier:
Biotium
Omschrijving:
This antibody recognizes a protein of 70 kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.
Leverancier:
Biotium
Omschrijving:
Recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
Itemnummer:
(AGRIAS10763)
Leverancier:
Agrisera
Omschrijving:
Anti-IgG (H+L) Goat Polyclonal Antibody (Biotin)
UOM:
1 * 2 mg
Itemnummer:
(AGRIAS09627)
Leverancier:
Agrisera
Omschrijving:
Anti-IgG (H+L) Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
UOM:
1 * 1 mg
Itemnummer:
(AGRIAS09610)
Leverancier:
Agrisera
Omschrijving:
Anti-IgY Goat Polyclonal Antibody (Biotin)
UOM:
1 * 2 mg
Itemnummer:
(AGRIAS10761)
Leverancier:
Agrisera
Omschrijving:
Anti-IgG (H+L) Goat Polyclonal Antibody
UOM:
1 * 2 mg
Itemnummer:
(AGRIAS10765)
Leverancier:
Agrisera
Omschrijving:
Anti-IgG (H+L) Goat Polyclonal Antibody (DyLight® 488)
UOM:
1 * 1 mg
Itemnummer:
(AGRIAS09623)
Leverancier:
Agrisera
Omschrijving:
Anti-IgG (H+L) Rabbit Polyclonal Antibody (DyLight® 488)
UOM:
1 * 1 mg
Itemnummer:
(BOSSBS-1668R)
Leverancier:
Bioss
Omschrijving:
Anti-XBP1 Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-1786R)
Leverancier:
Bioss
Omschrijving:
Anti-CCNH Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-1508R)
Leverancier:
Bioss
Omschrijving:
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-1516R)
Leverancier:
Bioss
Omschrijving:
CNTF Receptor alpha is a receptor belonging to the cytokine superfamily of receptors. Along with LIFR and gp130, CNTF Receptor alpha forms the heterotrimeric CNTF receptor complex. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. During signal transduction, CNTF first binds to CNTF Recepror alpha, and this permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-16249R)
Leverancier:
Bioss
Omschrijving:
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).
UOM:
1 * 100 µl
Leverancier:
Biotium
Omschrijving:
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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