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Eiwitten en peptiden
Itemnummer:
(PRSI92-574)
Leverancier:
ProSci Inc.
Omschrijving:
The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% to 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerisation and heterodimerisation with ErbB2, resulting in cell signallling, heterodimerisation tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signalling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumours. Several anti-cancer drugs use EGFR as target.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-389)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin 1 receptor-like 1(IL1RL1) is a member of the interleukin-1 receptor family, Contains 3 Ig-like C2-type domains and 1 TIR domain. It is highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. IL1RL1 is a receptor for interleukin-33, its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 may possibly be involved in helper T-cell function. Soluble IL1RL1 also acts as a negative regulator of Th2 cytokine production, it directly implicated in the progression of cardiac disease.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-402)
Leverancier:
ProSci Inc.
Omschrijving:
Cryptic (CFC1) is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. It contains an EGF-like domain, and is glycosylated on its N-terminal during post-translational modification. Cryptic is identified as a NODAL coreceptor involved in the correct establishment of the left-right axis. It may play a role in mesoderm and/or neural patterning during gastrulation. The unnormal expression of this gene may causes a series of diseases such as HTX2, Transposition of the great arteries dextro-looped 2, and Conotruncal heart malformations.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-178)
Leverancier:
ProSci Inc.
Omschrijving:
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In addition, FGF-9 may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-094)
Leverancier:
ProSci Inc.
Omschrijving:
FGF-21 (Fibroblast growth factor 21) stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of betaKlotho.
UOM:
1 * 1 EA
Itemnummer:
(PRSI6165P)
Leverancier:
ProSci Inc.
Omschrijving:
FBXL16 peptide is used for blocking the activity of FBXL16 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4697P)
Leverancier:
ProSci Inc.
Omschrijving:
LASS5 peptide is used for blocking the activity of LASS5 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3387P)
Leverancier:
ProSci Inc.
Omschrijving:
TAB1 peptide is used for blocking the activity of the TAB1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6189P)
Leverancier:
ProSci Inc.
Omschrijving:
RHAMM peptide is used for blocking the activity of RHAMM antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4651P)
Leverancier:
ProSci Inc.
Omschrijving:
Slc22A17 peptide is used for blocking the activity of Slc22A17 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4659P)
Leverancier:
ProSci Inc.
Omschrijving:
CLIP170 peptide is used for blocking the activity of CLIP170 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4661P)
Leverancier:
ProSci Inc.
Omschrijving:
Bst2 peptide is used for blocking the activity of Bst2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-461)
Leverancier:
ProSci Inc.
Omschrijving:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-017)
Leverancier:
ProSci Inc.
Omschrijving:
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-562)
Leverancier:
ProSci Inc.
Omschrijving:
Alpha-N-Acetylgalactosaminide alpha-2,6-Sialyltransferase 2 (ST6GALNAC2) belongs to the glycosyltransferase 29 family that adds sialic acids to the non-reducing ends of glycoconjugates. At the cell surface, these modifications play roles in cell-cell and cell-substrate interactions, bacterial adhesion and protein targeting. ST6GALNAC2 is localized to the Golgi apparatus membrane. ST6GALNAC2 is highly expressed in lactating mammary glands and the adult testis; it is expressed at lower levels in the kidney. ST6GALNAC2 can catalyze 2,6-sialylation of the Tn antigen.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4607P)
Leverancier:
ProSci Inc.
Omschrijving:
Slc35D1 peptide is used for blocking the activity of Slc35D1 antibody.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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