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Eiwitten en peptiden
Itemnummer:
(PRSI5165P)
Leverancier:
ProSci Inc.
Omschrijving:
SCF peptide is used for blocking the activity of SCF antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6055P)
Leverancier:
ProSci Inc.
Omschrijving:
PEAR1 peptide is used for blocking the activity of PEAR1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-616)
Leverancier:
ProSci Inc.
Omschrijving:
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
UOM:
1 * 1 EA
Itemnummer:
(PRSI6061P)
Leverancier:
ProSci Inc.
Omschrijving:
STOX2 peptide is used for blocking the activity of STOX2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7031P)
Leverancier:
ProSci Inc.
Omschrijving:
MYCT1 peptide is used for blocking the activity of MYCT1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7043P)
Leverancier:
ProSci Inc.
Omschrijving:
ATG14 peptide is used for blocking the activity of ATG14 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7103P)
Leverancier:
ProSci Inc.
Omschrijving:
WIPI2 Peptide is used for blocking the activity of WIPI2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5411P)
Leverancier:
ProSci Inc.
Omschrijving:
RUSC1 peptide is used for blocking the activity of RUSC1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7037P)
Leverancier:
ProSci Inc.
Omschrijving:
SGSM3 peptide is used for blocking the activity of SGSM3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-502)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin-12 (IL-12), also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL-12 activities include the induction of IFN-gamma and TNF in resting and activated T and NK cells; the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen; and the enhancement of NK cell proliferation. Current evidence indicates that IL-12 is a key mediator of cellular immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular immunity and as an antitumour and anti viral agent.
UOM:
1 * 25 µG
Itemnummer:
(PRSI92-694)
Leverancier:
ProSci Inc.
Omschrijving:
Tumour necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumour necrosis factor receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. CD137 is expressed by mesenchymal cells, including endothelial cells, chondrocytes, and cells of the central nervous system. CD137 is also broadly expressed by cells of the human immune system, is broadly expressed by cells of the human immune system, including activated CD8+ and CD4+ T cells, activated natural killer (NK) cells, follicular dendritic cells (FDCs) and monocytes. CD137 has diverse roles in the immune response, the one key function is to promote the survival of both T cells and dendritic cells by binding the cognate ligand CD137L (4-1BBL).
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-693)
Leverancier:
ProSci Inc.
Omschrijving:
Tumour necrosis factor receptor superfamily member 1A (TNFRSF1A) is a member of the tumour necrosis factor receptor superfamily. TNFRSF1A is one of the major receptors for the tumour necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumour necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-152)
Leverancier:
ProSci Inc.
Omschrijving:
CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-702)
Leverancier:
ProSci Inc.
Omschrijving:
Lysosome membrane protein II (LIMPII)，also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganisation of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. In addition, LIMPII also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-242)
Leverancier:
ProSci Inc.
Omschrijving:
Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4). DLL4 contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 plays a role in the Notch signaling pathway. DLL4 activates Notch-1 and Notch-4.
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-067)
Leverancier:
ProSci Inc.
Omschrijving:
The Galectin family of proteins, with specificity for Nacetyllactosaminecontaining glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). At least 14 mammalian galectins family members, which share structural similarities in their carbohydrate recognition domains (CRD), have been identified to date. Unlike the selectin family of proteins, the carbohydrate binding specificity of galectins is calcium-independent. A common function of galectins is to cross-link structures containing N-acetyl-lactosamine located at the cell surface and within the extracellular matrix. They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide, galectins can also be secreted by one or more unidentified, non-classical, secretory pathways. They have diverse effects on many cellular functions including adhesion, migration, polarity, chemotaxis, proliferation, apoptosis, and differentiation. Galectins may therefore play a key role in many pathological states, including autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetic complications. The galectins have been classified into the prototype galectins(1, 2, 5, 7, 10, 11, 13, 14), which contain one CRD and exist either as a monomer or a noncovalent homodimer. The chimera galectins(Galectin3) containing one CRD linked to a nonlectin domain, and the tandemrepeat Galectins(4, 6, 8, 9, 12) consisting of two CRDs joined by a linker peptide.Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions. However, via one or more as yet unidentified nonclassical secretory pathways, galectins can also be secreted to function extracellularly. Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities. Each family member may preferentially bind to a unique subset of cell surface glycoproteins.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
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