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Eiwitten en peptiden
Itemnummer:
(PRSI3045P)
Leverancier:
ProSci Inc.
Omschrijving:
p53DINP1 peptide is used for blocking the activity of p53DINP1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3041P)
Leverancier:
ProSci Inc.
Omschrijving:
PUMA peptide is used for blocking the activity of PUMA antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3459P)
Leverancier:
ProSci Inc.
Omschrijving:
Caspase-1 peptide is used for blocking the activity of Caspase-1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7097P)
Leverancier:
ProSci Inc.
Omschrijving:
PANX1 Peptide is used for blocking the activity of PANX1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-659)
Leverancier:
ProSci Inc.
Omschrijving:
Trem-like transcript 2 protein (TLT2), also known as Triggering receptor expressed on myeloid cells-like protein 2, TLT2 and C6orf76, is single-pass type I membrane protein. TREML2 contains one Ig-like V-type domain, which can be induced in CD4 T-cell by concanavalin-A. As a cell surface receptor, TREML2 may play a role in the innate and adaptive immune response. TREML2 also acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. It has shown that TREML2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5969P)
Leverancier:
ProSci Inc.
Omschrijving:
NALP11 peptide is used for blocking the activity of NALP11 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5975P)
Leverancier:
ProSci Inc.
Omschrijving:
NALP14 peptide is used for blocking the activity of NALP14 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-298)
Leverancier:
ProSci Inc.
Omschrijving:
CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-292)
Leverancier:
ProSci Inc.
Omschrijving:
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytoplasmic ITIM (immunoreceptor tyrosinebased inhibitory motif). The receptor-substrate interaction may function as a myeloid downregulatory signal.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-293)
Leverancier:
ProSci Inc.
Omschrijving:
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6945P)
Leverancier:
ProSci Inc.
Omschrijving:
DDX60 peptide is used for blocking the activity of DDX60 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-682)
Leverancier:
ProSci Inc.
Omschrijving:
Phosphatidylinositol 4-Kinase beta (PI4KB) belongs to the PI3/PI4-kinase family and Type III PI4K subfamily. PI4KB contains one PI3K/PI4K domain and one PIK helical domain. It is highly expressed in heart, skeletal muscle, pancreas, testis and ovary,; it is lowly expressed in liver tissue. PI4KB kinase activity can be inhibited by wortmannin, and increased by interacting with NCS1/FREQ. PI4KB phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). In addition, PI4KB may regulate Golgi disintegration/reorganization during mitosis.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4277P)
Leverancier:
ProSci Inc.
Omschrijving:
ADAP peptide is used for blocking the activity of ADAP antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-323)
Leverancier:
ProSci Inc.
Omschrijving:
Fibroblast growth factor 21 (FGF-21) is a member of the fibroblast growth factor family and has been identified as an important regulator of energy metabolism connecting nutrition, growth, reproduction and longevity. FGF-21 lacks the heparin-binding domain of most FGF proteins, allowing its secretion. FGF-21 is abundantly expressed in adipose tissues, liver and pancreas. In adipose tissue, FGF-21 promotes glucose uptake and oxidation and in liver it replenishes on fasting the tissues with fuel on low nutritional supply. It also induces lipolysis and ketogenesis. FGF-21 acts through FGF receptors (FGFR) associated with the auxiliary protein beta-Klotho. Recently, FGF-21 has been reported to interact directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting. Due to its multiple functions of normalizing glucose, lipid and energy homeostasis, FGF-21 represents an attractive novel therapy for type 2 diabetes mellitus and obesity.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-319)
Leverancier:
ProSci Inc.
Omschrijving:
Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognises beta-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognises alpha-mannans and transduces its signal through association with the ITAM-containing Fc receptor gamma-chain.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-484)
Leverancier:
ProSci Inc.
Omschrijving:
Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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