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Eiwitten en peptiden
Itemnummer:
(PRSI92-297)
Leverancier:
ProSci Inc.
Omschrijving:
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-298)
Leverancier:
ProSci Inc.
Omschrijving:
neuregulin-1 (heregulin-1，NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-474)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. IL21R contains two fibronectin type-III domains. IL21R is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells.
UOM:
1 * 200 µG
Itemnummer:
(PRSI4441P)
Leverancier:
ProSci Inc.
Omschrijving:
ATG5 peptide is used for blocking the activity of ATG5 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5579P)
Leverancier:
ProSci Inc.
Omschrijving:
LXR-B peptide is used for blocking the activity of LXR-B antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5571P)
Leverancier:
ProSci Inc.
Omschrijving:
REEP2 peptide is used for blocking the activity of REEP2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4331P)
Leverancier:
ProSci Inc.
Omschrijving:
BRCC36 peptide is used for blocking the activity of BRCC36 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4027P)
Leverancier:
ProSci Inc.
Omschrijving:
CRTH2 peptide is used for blocking the activity of CRTH2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-016)
Leverancier:
ProSci Inc.
Omschrijving:
Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent growth factor for fibroblasts and endothelial cells. FGF acidic is involved in wound repair, angiogenesis, and development. FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism. The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling. There are four distinct FGF receptors and each has multiple splice variants. FGF acidic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLCγ/PKC, and PI3K/Akt pathways.
UOM:
1 * 200 µG
Itemnummer:
(PRSI90-542)
Leverancier:
ProSci Inc.
Omschrijving:
Stem cell factor (SCF), also known as cKit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilisaion of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/cKit to trigger receptor dimerisaion and signalling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-246)
Leverancier:
ProSci Inc.
Omschrijving:
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be detected in the adult brain, liver, lung, heart, stomach, spleen and testis. It is expressed in fetal liver and adult skeletal muscle. CLIC2 is a potential candidate for one of many diseases linked to Xq28.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5739P)
Leverancier:
ProSci Inc.
Omschrijving:
APC13 peptide is used for blocking the activity of APC13 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-649)
Leverancier:
ProSci Inc.
Omschrijving:
Follistatin-like 1 (FSTL1) is a secreted glycoprotein that has been grouped into the follistatin family of proteins. FSTL1 is composed of a follistatin domain and two non-functional calcium-binding motifs. It was originally cloned as a TGF beta 1 inducible factor but subsequently shown to regulate diverse developmental pathways and tissue homeostasis. Ablation of the FSTL1 gene in the mouse results in several structural developmental defects and neonatal lethality due to respiratory failure. FSTL1 suppresses BMP signalling, but the precise mechanism of its action has not been elucidated. FSTL1 is expressed in the human placenta, mainly in extra villous trophoblasts.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6163P)
Leverancier:
ProSci Inc.
Omschrijving:
AXIN2 peptide is used for blocking the activity of AXIN2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6167P)
Leverancier:
ProSci Inc.
Omschrijving:
LRRTM1 peptide is used for blocking the activity of LRRTM1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6129P)
Leverancier:
ProSci Inc.
Omschrijving:
ZBTB8 peptide is used for blocking the activity of ZBTB8 antibody.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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