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Eiwitten en peptiden
Itemnummer:
(PRSI90-284)
Leverancier:
ProSci Inc.
Omschrijving:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-455)
Leverancier:
ProSci Inc.
Omschrijving:
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5853P)
Leverancier:
ProSci Inc.
Omschrijving:
SCRN3 peptide is used for blocking the activity of SCRN3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5839P)
Leverancier:
ProSci Inc.
Omschrijving:
ZC3HAV1 peptide is used for blocking the activity of ZC3HAV1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-068)
Leverancier:
ProSci Inc.
Omschrijving:
Microfibril-associated protein 4 (MFAP4) was initially identified as a gene commonly deleted in the contiguous Smith-Magenis syndrome (SMS) gene. MFAP4 was identified as growth factor to support expansion of hematopoietic stem cells in culture. It is involved in calcium-dependent cell adhesion and intercellular interactions.
UOM:
1 * 1 EA
Itemnummer:
(PRSI5059P)
Leverancier:
ProSci Inc.
Omschrijving:
CDIP peptide is used for blocking the activity of CDIP antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5023P)
Leverancier:
ProSci Inc.
Omschrijving:
SPG15 peptide is used for blocking the activity of SPG15 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5061P)
Leverancier:
ProSci Inc.
Omschrijving:
GNPDA2 peptide is used for blocking the activity of GNPDA2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-395)
Leverancier:
ProSci Inc.
Omschrijving:
Heat shock protein HSP 90-alpha (HSP90AA1 or HSP90A) is also known as Heat shock 86 kDa (HSP 86 or HSP86), Renal carcinoma antigen NY-REN-38, HSPC1, HSPCA, EL52, HSP89A, HSP90N, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2, which belongs to the heat shock protein 90 family. HSP90AA1 undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. HSP90AA1 interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
UOM:
1 * 1 EA
Itemnummer:
(PRSI5811P)
Leverancier:
ProSci Inc.
Omschrijving:
FOXO1 peptide is used for blocking the activity of FOXO1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-599)
Leverancier:
ProSci Inc.
Omschrijving:
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumour growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5815P)
Leverancier:
ProSci Inc.
Omschrijving:
FOXO4 peptide is used for blocking the activity of FOXO4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5829P)
Leverancier:
ProSci Inc.
Omschrijving:
FREM1 peptide is used for blocking the activity of FREM1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-723)
Leverancier:
ProSci Inc.
Omschrijving:
Uroplakin-2 is a single-pass type I membrane protein that belongs to the uroplakin-2 family. Uroplakin-2 is a component of the asymmetric unit membrane (AUM) and expressed in the ureter, a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. Uroplakin-2 forms heterodimer with UPK1A that is necessary for exiting out of the endoplasmic reticulum (ER). Uroplakin-2 may play an important role in regulating the assembly of the AUM. AUM is believed to strengthen the urothelium by preventing cell rupture during bladder distention.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-715)
Leverancier:
ProSci Inc.
Omschrijving:
Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), beta -galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-708)
Leverancier:
ProSci Inc.
Omschrijving:
MANSC domain-containing protein 1(MANSC1) is encoded by MANSC1 gene. MANSC1 is a Single-pass type I membrane protein which contains 1 MANSC domain. It is widely expressed in many tissues and mainly located in membrane.
UOM:
1 * 50 µG
Bel voor prijs
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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