Masterflex+Single-use+Flow+Sensor
Numéro de catalogue:
(PRSI55-079)
Fournisseur:
ProSci Inc.
Description:
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon.
UOM:
1 * 400 µl
New Product
Numéro de catalogue:
(BSBTPB9147)
Fournisseur:
BosterBio
Description:
Polyclonal antibody for MUC-4/MUC4 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. MUC-4/MUC4 information: Molecular Weight: 231518 MW; Subcellular Localization: Membrane ; Single-pass membrane protein . Secreted . Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing; Tissue Specificity: Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines.
UOM:
1 * 1 EA
Fournisseur:
Merck
Description:
La sonde de température mesure la température réelle dans le puit du bloc à réaction et la compare à la température de consigne. Les résultats peuvent être transmis vers un PC pour documentation.
Numéro de catalogue:
(PRSI5057)
Fournisseur:
ProSci Inc.
Description:
FNIP2 Antibody: FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI2505)
Fournisseur:
ProSci Inc.
Description:
Livin Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP. Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-alpha and Livin-beta. Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5139)
Fournisseur:
ProSci Inc.
Description:
MATN1 Antibody: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN1 is composed of two Willebrand Factor A (vWFA) domains separated by one EGF-like domain, whereas MATN3 is composed of a single N-terminal vWFA domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that the MATN1 promoter region was associated with both susceptibility and disease progression in Adolescent idiopathic scoliosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-952)
Fournisseur:
ProSci Inc.
Description:
T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(466-0310)
Fournisseur:
Thermo Fisher Scientific
Description:
Électrode, autre, Capteur d'échantillon
UOM:
1 * 1 ST
Fournisseur:
VARIAN
Description:
Bond Elut™ PPL is a styrene-divinylvenzene (SDVB) polymer that has been modified with a proprietary non-polar surface. PPL will retain even the most polar classes of analytes, including phenols. The large particle size allows ease of flow for viscous or particulate rich water samples, while the high surface area and strong hydrophobicity ensure reproducible extractions with high recoveries upon elution. Bond Elut™ PPL is suitable for EPA Method 528 ‘Determination of Phenols in Drinking Water by SPE and Capillary GC/MS’.
Fournisseur:
Hach
Description:
Kit de Capuchon de sonde de rechange, comprenant un capuchon de sonde et iButton, pour IntelliCAL LBOD101, Pour: Sonde pour oxygène dissous optique IntelliCAL™ LDO101, Sonde à oxygène dissous
Numéro de catalogue:
(PRSI92-397)
Fournisseur:
ProSci Inc.
Description:
Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells, platelet aggregation, and cytoskeleton reorganisation. Not only these, it also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signalling SOCS1 and SOCS3. In addition, MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE), deficiency in MERTK are the cause of retinitis pigmentosa.
UOM:
1 * 50 µG
Numéro de catalogue:
(231-0251)
Fournisseur:
HAMMACHER KARL
Description:
En acier inoxydable, droites. Spécialement conçues pour l'arrêt ou la régulation du débit dans les raccords de tuyaux.
UOM:
1 * 1 ST
Numéro de catalogue:
(ENDRCPS91E-AA7BTH4)
Fournisseur:
Endress+Hauser
Description:
Memosens 2.0 pH electrode for heavily soiled media in chemical processes, paper or paint production.
UOM:
1 * 1 ST
New Product
Numéro de catalogue:
(PRSI4781)
Fournisseur:
ProSci Inc.
Description:
IL-34 Antibody: Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages.
UOM:
1 * 1 EA
Fournisseur:
REVCO TECHNOLOGIES
Description:
With precise temperature control and stability of all culture parameters, the Series 8000 direct-heat CO₂ incubators offer dependable flexibility for growing cells. The automatic high-temperature decontamination cycle is ideal for overnight sterilisation and ensures consistent sterilisation time after time. Units are light weight and easy to move with accessory roller base, there is a choice of TC or IR CO₂ sensor.
Numéro de catalogue:
(PRSI56-607)
Fournisseur:
ProSci Inc.
Description:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.
UOM:
1 * 400 µl
New Product
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