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Single-use+Temperature+Sensor
Numéro de catalogue:
(BOSSBS-2771R-A350)
Fournisseur:
Bioss
Description:
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.
UOM:
1 * 100 µl
Fournisseur:
MOTIC
Description:
Ces stéréomicroscopes numériques avec zoom conviennent aux applications d'assemblage et d'inspection.
Numéro de catalogue:
(PRSI3027)
Fournisseur:
ProSci Inc.
Description:
NALP2 Antibody: NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1 beta -processing activity and is thought to function as a modulator of NF-kappa B and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
UOM:
1 * 1 EA
Numéro de catalogue:
(ENDRCLS15E-1061/0)
Fournisseur:
Endress+Hauser
Description:
A digital sensor for low measuring ranges, suitable for applications such as boiler feed water monitoring and chip cleaning. Benefit from its extended data storage functions that enable predictive maintenance.
UOM:
1 * 1 ST
Fournisseur:
Thermo Scientific
Description:
Système de sauvegarde au CO₂ installé sur site pour les congélateurs ULT des séries TSX, RLE, HLE et TLE, capacité de 400 à 700 boîtes : maintient la température jusqu'à −67 °C avec du CO₂ (les modèles pour HLE300 sont autonomes)
Fournisseur:
Greisinger
Description:
Électrode, pH, GE 100, pH: 0 - 14, 0...80 °C, Membrane: 2× ceramic, Électrolyte: 3 mol/l KCl, refillable, Ø×L: 12×120 mm, 1 m cable with BNC plug, Pour: General purpose
Fournisseur:
Binder
Description:
Ces congélateurs à température ultra basse garantissent le stockage sûr d’échantillons à –90 °C. Ils combinent un excellent respect de l’environnement, une faible consommation d’énergie, un
fonctionnement commode et la sécurité individuelle.
Numéro de catalogue:
(662-1532)
Fournisseur:
Thermo Orion
Description:
Combination pH electrode with epoxy body for fast response in difficult samples and soils.
UOM:
1 * 1 ST
Numéro de catalogue:
(ENZOADISPA845D)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The 90kDa molecular chaperone family includes 90 kDa heat shock protein Hsp90 and 94 kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells contain isoforms Hsp90α and Hsp90β, encoded by separate genes. The amino acid sequences of human and yeast Hsp90-alpha are 85% and 90% homologous to those of Hsp90β , respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 functions as part of the cell’s powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions. In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signaling and cell cycle control. In this context, researchers identified key regulatory proteins as substrates of Hsp90, including steroid receptors, cell cycle kinases involved in signal transduction, and p53. Hsp90 may act as a capacitor for morphological evolution by buffering widespread variation, potentially affecting morphogenic pathways. When temperature and other stress factors compromise Drosophila Hsp90 buffering, cryptic variant expression occurs, and selection can lead to the continued expression of these traits even after Hsp90 function is restored.
UOM:
1 * 50 µl
New Product
Fournisseur:
UVP ULTRA VIOLET PRODUCTS
Description:
The J-Series UV meters are photovoltaic devices for taking repeatable readings of UV light sources in either the 365 nm or 254 nm UV range.
Numéro de catalogue:
(ENZOADISPA845F)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The 90 kDa molecular chaperone family includes 90 kDa heat shock protein Hsp90 and 94 kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells contain isoforms Hsp90α and Hsp90β, encoded by separate genes. The amino acid sequences of human and yeast Hsp90-alpha are 85% and 90% homologous to those of Hsp90β , respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1 to 2% of all cellular proteins in most cells. Hsp90 functions as part of the cell’s powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions. In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signaling and cell cycle control. In this context, researchers identified key regulatory proteins as substrates of Hsp90, including steroid receptors, cell cycle kinases involved in signal transduction, and p53. Hsp90 may act as a capacitor for morphological evolution by buffering widespread variation, potentially affecting morphogenic pathways. When temperature and other stress factors compromise Drosophila Hsp90 buffering, cryptic variant expression occurs, and selection can lead to the continued expression of these traits even after Hsp90 function is restored.
UOM:
1 * 200 µl
New Product
Fournisseur:
Mettler - Toledo
Description:
Ideal for critical samples such as suspensions or samples of unknown composition (e.g. wastewater).
Fournisseur:
HORIBA
Description:
Bouchon à membrane pour capteur DO
Numéro de catalogue:
(AATB21508)
Fournisseur:
AAT BIOQUEST INC
Description:
Thiolite™ Green is one of the most sensitive sensors for measuring thiol compounds.
UOM:
1 * 5 mg
New Product
Fournisseur:
Mettler - Toledo
Description:
This conductivity measuring cell utilises the four- pole potentiometric method for measuring conductivity, which incorporates a series of four graphite poles embedded in the probe shaft. This design completely eliminates the polarisation, which frequently occurs with the two-plate amperometric method during measuring high conductivity solution.
Numéro de catalogue:
(LOVI194300)
Fournisseur:
Lovibond
Description:
Ideal for field and environmental testing, the TB350 turbidity meter delivers the most reliable measurements for low range to high range samples with unreached accuracy over the complete range. Its new Multipath 90° BLAC® sensor technology makes it the best instrument on the market. Get lab accuracy in a portable solution.
UOM:
1 * 1 ST
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