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Protéines et Peptides
Numéro de catalogue:
(PRSI90-424)
Fournisseur:
ProSci Inc.
Description:
BTLA is a type I transmembrane glycoprotein of the CD28 family of T cell costimulatory molecules. BTLA functions as a coinhibitor on activated T cells and on B cells and dendritic cells. The extracellular domain (ECD) of this Ig superfamily protein contains one V-type Ig-like domain, which interacts with HVEM.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-425)
Fournisseur:
ProSci Inc.
Description:
T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumour cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5667P)
Fournisseur:
ProSci Inc.
Description:
Maelstrom peptide is used for blocking the activity of Maelstrom antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-831)
Fournisseur:
ProSci Inc.
Description:
CXCL16 is a single-pass type I membrane protein, which consists of 246 amino acids, CXCL16 induces a strong chemotatic response and calcium mobilization. CXCL16 acts as a scavenger receptor on macrophages, which specially binds to oxidized low density lipoprotein. CXCL16 may involves in pathophysiology such as atherogenesis. Soluble CXCL16 may play an important role in liver metastases through the induction of epithelial-mesenchymal transition.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-835)
Fournisseur:
ProSci Inc.
Description:
Ephrin-A4 belongs to the ephrin family and Contains 1 ephrin RBD (ephrin receptor-binding) domain. The protein is cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Ephrin-A4 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It may play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-837)
Fournisseur:
ProSci Inc.
Description:
Ephrin-B1, also named EFL-3, ELK ligand, EPH-related receptor tyrosine kinase ligand 2, is a single-pass type I membrane protein. It contains 1 ephrin RBD (ephrin receptor-binding) domain and belongs to the ephrin family. Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. Ephrin-B1 has been shown to bind EphA3, EphB1, EphB2, EphB3, and EphB4. The extracellular domains of human and mouse ephrin-B1 share 94% amino acid identity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-824)
Fournisseur:
ProSci Inc.
Description:
Semaphorin-4B is a single-pass type I membrane protein. SEMA4B is a member of the semaphorin family. The class 4 semaphorins are integral membrane proteins that are widely expressed throughout the nervous system. SEMA4B is a single-pass type I membrane protein and contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one Sema domain. Human SEMA4B is expressed in neurons. SEMA4B inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. SEMA4B negatively regulates basophil-mediated Th2 and humoral memory responses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6799P)
Fournisseur:
ProSci Inc.
Description:
RLP2 peptide is used for blocking the activity of RLP2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4539P)
Fournisseur:
ProSci Inc.
Description:
AIFM3 peptide is used for blocking the activity of AIFM3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7333P)
Fournisseur:
ProSci Inc.
Description:
19 amino acid peptide near the carboxy terminus of human APO-E.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7327P)
Fournisseur:
ProSci Inc.
Description:
16 amino acids near the carboxy terminus of human GBP5.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7303P)
Fournisseur:
ProSci Inc.
Description:
15 amino acid peptide near the center of human CNRIP1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-342)
Fournisseur:
ProSci Inc.
Description:
PARP-3 [ARTD3] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signalling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-344)
Fournisseur:
ProSci Inc.
Description:
CREB-binding protein acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
UOM:
1 * 2 µG
Numéro de catalogue:
(PRSI90-348)
Fournisseur:
ProSci Inc.
Description:
NF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kappaB sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappaB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappaB inhibitor (I-kappaB) family. In a conventional activation pathway, I-kappaB is phosphorylated by I-kappaB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappaB complex which translocates to the nucleus. NF-kappaB heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappaB p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappaB complex.
UOM:
1 * 2 µG
Numéro de catalogue:
(PRSI96-013)
Fournisseur:
ProSci Inc.
Description:
Disintegrin and metalloproteinase domain-containing protein 8 is also known as ADAM8, Cell surface antigen MS2 and CD antigen CD156a, which belongs to the ADAM (a disintegrin and metalloprotease domain) family. ADAM family play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. ADAM8 / CD156a contains 1 disintegrin domain, 1 EGF-like domain and 1 peptidase M12B domain. ADAM8 / MS2 / CD156a is expressed on neutrophils and monocytes. ADAM8 / MS2 possible involvement in extravasation of leukocytes.
UOM:
1 * 50 µG
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