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Protéines et Peptides
Numéro de catalogue:
(PRSI91-185)
Fournisseur:
ProSci Inc.
Description:
Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression reduce of ANXA2 is associated with osteosarcoma metastases. ANXA2 functions as an autocrine factor, it can increases osteoclast formation and bone resorption. ANXA2 is involved in muscular dystrophies. In humans, the up-regulation of ANXA2 is related with colon adenocarcinoma cell differentiation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-431)
Fournisseur:
ProSci Inc.
Description:
Interleukin 13 receptor, alpha 1 is also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI96-365)
Fournisseur:
ProSci Inc.
Description:
Human Immunodeficiency Virus (HIV) can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa. HIV-2 is related to viruses found in sooty mangabeys. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Some of the HIV-1 group M subtypes are known to be more virulent or are resistant to different medications. HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses.
Envelope glycoprotein GP120 (or gp120) is the name of the glycoprotein which forms the spikes sticking out of a HIV virus particle. gp120 is essential for virus entry into cells as it plays a vital role in seeking out specific cell surface receptors for entry. Three gp120s, bound as heterodimers to a transmembrane glycoprotein, gp41, are thought to combine in a trimer to form the envelope spike, which is involved in virus-cell attachment. One half of the molecular weight of gp120 is due to the carbohydrate side chains (the "glyco-" in "glycoprotein"). These are sugar residues which form something almost like a sugar "dome" over the gp120 spikes. This dome prevents gp120 from being recognised by the human immune response. As the HIV virus and the human CD4 cell come together, the gp120 binding site "snaps open" at the last minute.The glycoprotein gp120 is anchored to the viral membrane, or envelope, via non-covalent bonds with the transmembrane glycoprotein, gp41. It is involved in entry into cells by binding to CD4 receptors, particularly helper T-cells. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-420)
Fournisseur:
ProSci Inc.
Description:
CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim) CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. CD160-Fc fusion protein targets a novel costimulatory pathway and prolongs allograft survival.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-421)
Fournisseur:
ProSci Inc.
Description:
CD200, also known as OX-2, is a 45 kDa transmembrane immunoregulatory protein that belongs to the immunoglobulin superfamily. CD200 is widely but not ubiquitously expressed. Its receptor (CD200R) is restricted primarily to mast cells, basophils, macrophages, and dendritic cells, which suggests myeloid cell regulation as the major function of CD200. CD200 knockout mice are characterised by increased macrophage number and activation and are predisposed to autoimmune disorders. In T cells, CD200 functions as a costimulatory molecule independent of the CD28 pathway. Several viruses encode CD200 homologs which are expressed on infected cells during the lytic phase. Like CD200 itself, viral CD200 homologs also suppress myeloid cell activity, enabling increased viral propagation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6377P)
Fournisseur:
ProSci Inc.
Description:
TYW3 peptide is used for blocking the activity of TYW3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6311P)
Fournisseur:
ProSci Inc.
Description:
NUMB peptide is used for blocking the activity of NUMB antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6379P)
Fournisseur:
ProSci Inc.
Description:
TYW4 peptide is used for blocking the activity of TYW4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-852)
Fournisseur:
ProSci Inc.
Description:
Complement factor H-related protein 5(FHR-5 for short), is a secreted protein which contains 9 Sushi (CCP/SCR) domains. It is expressed by the liver and secreted in plasma. The pattern of the deposits is similar to other complement components, suggesting that FHR-5 may play a role in complement activation and regulation. Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-856)
Fournisseur:
ProSci Inc.
Description:
Vasoactive intestinal peptide is also known as the vasoactive intestinal polypeptide or VIP. In humans, it is encoded by the VIP gene. VIP is neuropeptide which belongs to a glucagon/secretin superfamily, the ligand of class II G protein-coupled receptors. VIP is produced in many tissues of vertebrates including the gut, pancreas and suprachiasmatic nuclei of the hypothalamus in the brain. VIP stimulates contractility in the heart, causes vasodilation, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. VIP has a half-life (t½) in the blood of about two minutes.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5665P)
Fournisseur:
ProSci Inc.
Description:
RANBP10 peptide is used for blocking the activity of RANBP10 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4249P)
Fournisseur:
ProSci Inc.
Description:
SLPI peptide is used for blocking the activity of SLPI antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6445P)
Fournisseur:
ProSci Inc.
Description:
ARHGAP39 peptide is used for blocking the activity of ARHGAP39 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4883P)
Fournisseur:
ProSci Inc.
Description:
Disp2 peptide is used for blocking the activity of Disp2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6451P)
Fournisseur:
ProSci Inc.
Description:
Coronin 7 peptide is used for blocking the activity of Coronin 7 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6439P)
Fournisseur:
ProSci Inc.
Description:
L1TD1 peptide is used for blocking the activity of L1TD1 antibody.
UOM:
1 * 50 µG
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