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Protéines et Peptides


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Protéines et Peptides

Proteins are used in routine laboratory procedures such as binding enzymes or coupling peptides to carrier proteins. These kits, mixture solutions, and collagen matrices fulfill a myriad of essential laboratory functions for developing relationships between proteins and other cellular components. The stimulating proteins offered have various amino acid arrangements and functions to fulfill any sample manipulation for testing purposes in any field.


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Numéro de catalogue: (PRSI91-584)

Fournisseur:  ProSci Inc.
Description:   Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessels and endothelial cell growth, increasing microvascular permeability, promoting cell migration and inhibiting apoptosis. Alternatively spliced transcript variants of VEGF-A encod either secreted or cell-associated isoforms. The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI90-209)

Fournisseur:  ProSci Inc.
Description:   IL-38 (IL-1F10) belongs to the IL-1 family. IL-38 is expressed in the fetal skin, spleen and tonsil, generally in the basal epithelia of skin and in proliferating B cells of the tonsil. IL-38 binds soluble IL-1 receptor type 1 and may be implicated in the regulation of adapted and innate immune responses.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI4025P)

Fournisseur:  ProSci Inc.
Description:   TSLP peptide is used for blocking the activity of TSLP antibody.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI5757P)

Fournisseur:  ProSci Inc.
Description:   SUMO3 peptide is used for blocking the activity of SUMO3 antibody.
UOM:  1 * 50 µG

Fournisseur:  ProSci Inc.
Description:   DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI91-128)

Fournisseur:  ProSci Inc.
Description:   Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI90-332)

Fournisseur:  ProSci Inc.
Description:   DLL3 (Delta-like protein 3; Delta3) inhibits primary neurogenesis. It plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 binds and activates Notch-1 or another Notch receptor. Defects in DLL3 are the cause of spondylocostal dysostosis type 1 (SCDO1).
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI90-325)

Fournisseur:  ProSci Inc.
Description:   Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI90-334)

Fournisseur:  ProSci Inc.
Description:   Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. The membrane receptor FNDC5 can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).
UOM:  1 * 1 EA

Fournisseur:  ProSci Inc.
Description:   CALCB is a member of the calcitonin family. CALCB is produced in both peripheral and central neurons. It is a potent peptide vasodilator and can function in the transmission of pain. In the spinal cord, the function and expression of CGRP may differ depending on the location of synthesis. CALCB is derived mainly from the cell bodies of motor neurons when synthesised in the ventral horn of the spinal cord and may contribute to the regeneration of nervous tissue after injury.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI92-229)

Fournisseur:  ProSci Inc.
Description:   HTN3 belongs to the histatin/statherin family. Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. Post-translational proteolytic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins 1 and 3 are primary products of HIS1and HIS2 alleles, respectively. Histatins are believed to have important non-immunological, anti-microbial function in the oral cavity.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI5251P)

Fournisseur:  ProSci Inc.
Description:   HAAO peptide is used for blocking the activity of HAAO antibody.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI91-481)

Fournisseur:  ProSci Inc.
Description:   Nogo-66 Receptor-Related Protein 3 (NgR3) has primary structures with NgR2 (NgRH1, NgRL3) and biochemical properties that are homologous to Nogo-66 receptor (NgR), and constitute a novel neuronal receptor protein family. NgR is GPI-anchored and contains eight leucine-rich repeats (LRR), it is the neuronal receptor for the myelin- associated proteins Nogo-A, OMgp (oligodendrocyte myelin glycoprotein), and MAG (myelin-associated glycoprotein) and mediates the inhibition of CNS axonal regeneration both in vitro and in vivo. NgR2 and NgR3 have similar structure and distinct but overlapping expression versus NgR. NgR2 can be metalloproteinase-cleaved to release a soluble ectodomain. NgR2 has also been shown to bind MAG, but ligands for NgR3 have not yet been determined. Mature huaman NgR3 shares 88%, 88%, 48% and 44% amino acid identity with mature mouse NgR3, rat NgR3, human NgRH1 and NgR, repectively.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI3665P)

Fournisseur:  ProSci Inc.
Description:   BAP31 peptide is used for blocking the activity of BAP31 antibody.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI3663P)

Fournisseur:  ProSci Inc.
Description:   TRAF2 peptide is used for blocking the activity of TRAF2 antibody.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI3675P)

Fournisseur:  ProSci Inc.
Description:   BAP31 peptide is used for blocking the activity of BAP31 antibody.
UOM:  1 * 50 µG
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