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Bioss
Numéro de catalogue:
(BOSSBS-12416R-CY5)
Fournisseur:
Bioss
Description:
Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1-6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9215R-A680)
Fournisseur:
Bioss
Description:
The cystatin superfamily is a well-established family of cysteine protease inhibitors. Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN and SA cystatins are extracellular (type 2); and the kininogens are type 3 cystatins which are intravascular proteins. All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes. Cystatin SA, cystatin S and cystatin SN are found primarily in saliva. Cystatin S and SN can also be expressed in tears, urine and seminal fluid. Cystatin C is a related protein which is expressed in brain, thymus, ovary, epididymis and vas deferens. Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate the inhibition of cathepsin proteins. The fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors and the response to systemic inflammation. High molecular weight kininogen (Kininogen HC) and low molecular weight kininogen (Kininogen LC) have varied roles, though they both inhibit the thrombin- and plasmin-induced aggregation of thrombocytes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1236R-FITC)
Fournisseur:
Bioss
Description:
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4258R-A750)
Fournisseur:
Bioss
Description:
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11770R-CY3)
Fournisseur:
Bioss
Description:
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8192R-CY5)
Fournisseur:
Bioss
Description:
CTAGE6
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8192R-CY3)
Fournisseur:
Bioss
Description:
CTAGE6
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11770R-CY5)
Fournisseur:
Bioss
Description:
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3380R)
Fournisseur:
Bioss
Description:
Anti-RB1 Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-10196R-CY3)
Fournisseur:
Bioss
Description:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6551R-A680)
Fournisseur:
Bioss
Description:
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13580R-HRP)
Fournisseur:
Bioss
Description:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger and BTB domain-containing protein 48 (ZBTB48), also known as Kruppel-related zinc finger protein 3 or HKR3, is a 688 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZBTB48 is expressed in the adrenal gland and neuroblastoma cell lines. ZBTB48 contains a BTB domain, also known as a POZ domain, which inhibits DNA binding and mediates homotypic and heterotypic dimerization. Characteristics of the BTB domain suggest that ZBTB48 functions as a transcription regulator.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-10200R-A488)
Fournisseur:
Bioss
Description:
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3381R)
Fournisseur:
Bioss
Description:
mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of Raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha. Rapamycin or amino acid withdrawal increases, whereas insulin strongly inhibits, the recovery of 4EBP1 and raptor on 7-methyl-GTP Sepharose. Partial inhibition of raptor expression by RNA interference (RNAi) reduces mTOR-catalyzed 4EBP1 phosphorylation in vitro. RNAi of C. elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3405R)
Fournisseur:
Bioss
Description:
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3374R)
Fournisseur:
Bioss
Description:
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.
UOM:
1 * 100 µl
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