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ENZO LIFE SCIENCES
Fournisseur:
ENZO LIFE SCIENCES
Description:
PDK-1 (Pyruvate dehydrogenase kinase-1) is a 48 kDa protein kinase. It is a member of the mitrochondrial matrix protein kinase family and is related to the histidine protein kinases found in prokaryotes. PDK-1 is responsible for phosphorylation and concomitant inactivation of pyruvate dehydrogenase.
Numéro de catalogue:
(ENZOADIKAPTF120E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Acetylation and methylation of lysine are important post-translational modifications that regulate numerous protein-protein and protein-DNA interactions. Lysine acetylation and methylation involves the transfer of acetylCoA, or one or more methyl groups, to the e-amino group of lysine by modifying enzymes and cofactors. Histones and transcription factors are the primary targets of lysine acetylation and methylation, with either modification capable of inducing gene silencing or expression due to differential regulation of cofactors. For example, varying degrees of mono-, di-, and tri-methylation or acetylation of histone H3 at lysine residue 9 are known to demark distinct chromatin regions during various states of gene activation (methylation) or repression (acetylation).
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADIKAMST001E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
β-Catenin, a vertebrate homologue of Drosophila armadillo encoded by the CTNNB1 gene, performs two functions in the cell: mediating cell-cell adhesion by association between E-cadherin and the cytoskeleton, and acting as a downstream transcriptional activator of Wnt signaling, a key player in such functions as embryonic development, the induction of cell polarity, and the determination of cell fate. In the absence of Wnt signaling, glycogen synthase kinase-3β (GSK-3β) phosphorylates any free β-catenin at the amino terminus. This results in adenomatous polyposis coli tumor suppressor protein (APC)-mediated β-catenin degradation via the ubiquitin-proteosome pathway. Wnt signaling stabilizes β-catenin by inhibiting the activity of GSK-3β and preventing β-catenin degradation. β-catenin forms complexes with DNA-binding proteins such as T-cell factor (Tcf) and lymphocyte-enhancer factor (Lef), which promote expression of a variety of target genes, including c-myc and cyclin D1.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADIKAPNO020F)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.
UOM:
1 * 200 µG
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2a) (IC50=2µM) and SAPK2b (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells.
Numéro de catalogue:
(ENZOBMLSE3490005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in insect cells. Active, full length protein kinase C nu (PKCν, protein kinase D3, PKD3) is fused at the N-terminus to a GST-tag.
UOM:
1 * 5 µG
New Product
Numéro de catalogue:
(ENZOBMLSE4040010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in Sf9 cells. Human VEGFR2 (aa 805-1356).
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOBMLSE4520100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>. Catalytic domain (aa 1319-1710) of human CBP.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOBMLSE4930010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in insect cells. Primarily full length latent MMP-13, with some active forms present.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOBMLSE4020010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>. Full length human PTEN (aa 1-403) is fused at the N-terminus to a His-tag.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOBMLSE4830100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>. Human 14-3-3beta is fused at the C-terminus to a His-tag.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOBMLSE5050005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Isolated from mouse fibroblasts. Primarily latent form.
UOM:
1 * 5 µG
New Product
Numéro de catalogue:
(ENZOBMLSE5000050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Highly active
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOADI901002)
Fournisseur:
ENZO LIFE SCIENCES
Description:
For the quantitative determination of TXB2 in culture supernatants, plasma, serum, saliva, and urine from any species. Cited sample types include cell lysate, coronary effluent, liver perfusate, platelets, rectal dialysate, and whole blood.
UOM:
1 * 1 KIT
New Product
Numéro de catalogue:
(ENZOADI901164)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Most sensitive (0,043 pmol/ml) and complete colorimetric kit for intra- and extracellular cGMP quantification.
UOM:
1 * 1 KIT
New Product
Numéro de catalogue:
(ENZOADI9002220001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Rapid ELISA kit to quantify SLPI, a secretory leukocyte peptidase inhibitor and unique cancer biomarker.
UOM:
1 * 1 KIT
New Product
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