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ENZO LIFE SCIENCES
Numéro de catalogue:
(ENZOBMLAK4020001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
A QuantiZyme™ Assay System. The MMP-12 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-12 (MMP-12, macrophage elastase, metalloelastase) using a thiopeptide as a chromogenic substrate. The assays are performed in a convenient 96-well plate format. Included are active enzyme, assay buffer, a prototypic control inhibitor (NNGH), and a detailed instruction booklet.
UOM:
1 * 1 KIT
New Product
Numéro de catalogue:
(ENZOBMLEI1180010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
A potent and specific substrate analog PLA2 inhibitor (IC50=6.2 µM-porcine pancreatic PLA2). It inhibits human recombinant sPLA2 (IC50=13.7 µM) selectively over cPLA2. At 1 µM it completely blocked the myogenic response in perfused dog renal arcuate arteries.
UOM:
1 * 10 mg
New Product
Numéro de catalogue:
(ENZOBMLEI1770001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Phospholipase inhibitor
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOBMLSE5420010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Isolated from human serum.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Anti-inflammatory, antioxidant and antimutagenic compound
Numéro de catalogue:
(ENZOADIEKS750)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Most comprehensive portfolio of heat shock protein (chaperone) products commercially available.
UOM:
1 * 1 KIT
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
CaMKIIa, the alpha subunit of Ca2+ calmodulin-dependent protein kinase II is part of a family of multifunctional protein kinases, which play a major role in Ca2+-mediated signal transduction. CaMKIIa is expressed in many different tissues but is specifically found in the neurons of the forebrain and its mRNA is found within the dendrites as well as the soma of the neuron. The neuronal CaMKII consists of two major subunits of 52 and 60 kDa which are encoded by a- and b-CaMKII genes, respectively. Additional isoforms are generated by alternative splicing of these as well as of the ubiquitious g- and d-CaMKII genes. Each subunit has an ATP-binding domain (arginine-X-X-serune/threonine), consensus phosphorylation site, catalytic domain, and a centrally located regulatory domain which has calmodulin binding activity. Activation and autophosphorylation of CaMKII may regulate numerous neuronal processes which includes two forms of synaptic plasticity, long term potentiation and long term depression. Neuronal CaMKII subunits assemble as large multimeric holoenzymes. The C-terminal association domains of 6-12 subunits assemble into a central globular structure from which the N-terminal catalytic/regulatory domains extend radially like petals of a flower. The subunit composition of the rat forebrain CaMKII holoenzyme consists of heteromers composed of a and β subunits at a ratio of 2:1 and homomers composed of only a subunits. The association of CaMKII subunits leads to the positioning of their catalytic/regulatory domains in close proximity and the neighboring calmodulin-bound subunits cooperate to rapidly phosphorylate each other. Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Protein Kinase C (PKC) is a large superfamily of serine/threonine kinases that mediate essential cellular signals required for activation, proliferation, differentiation and survival. There are at least ten PKC isotypes that are closely related in structure but that have distinct patterns of tissue distribution and function. The PKC isotypes can be subdivided into three classes based on primary structure and biochemical properties. These are: classical or conventional PKC isotypes (cPKC), novel PKC isotypes (nPKC) and atypical PKC isotypes (aPKC).
Numéro de catalogue:
(ENZOBMLSE1020001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Isolated from bovine brain. Calmodulin conjugated to 4% cross-linked agarose beads via a 5 atom hydrophilic spacer arm.
UOM:
1 * 1 mL
New Product
Numéro de catalogue:
(ENZOBMLSE1705000)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>.
UOM:
1 * 1 VIA
New Product
Numéro de catalogue:
(ENZOBMLSE1090010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>. Active Matrix Metalloproteinase-3 (MMP-3, stromelysin-1, transin) catalytic domain from human cDNA.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADICSA330E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The epidermal growth factor receptor (EGFR) is a 170-kDa membrane bound receptor consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and a tyrosine kinase domain-containing cytoplasmic region. Ligand binding induces receptor homo- or heterodimerization, triggering autophosphorylation of cytoplasmic tyrosine residues that provide docking sites for Src homology 2 (SH2) domain-containing signaling molecules. Src-mediated phosphorylation of EGFR at Tyr845 may contribute to EGFR hyperactivity in cancer, while autophosphorylation of EGFR at Tyr1068 and/or Tyr1173 in response to ligand binding is known to recruit cofactors (e.g. SHP1, RasGAP, SOS1, Grb2) that activate pathways associated with cell growth, apoptosis, adhesion, receptor endocytosis, and protein degradation.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADIEKS400A)
Fournisseur:
ENZO LIFE SCIENCES
Description:
This is a non-radioactive Akt kinase activity assay, providing a safe, rapid and reliable method for the screening of inhibitors or activators of Akt and for quantitating the activity of Akt in purified or partially purified enzyme preparations. The Akt Kinase activity kit is based on a solid phase enzyme immunoassay (EIA) that utilizes a specific synthetic peptide as a substrate for Akt and a polyclonal antibody that recognizes the phosphorylated form of the substrate. The assay is designed for the analysis of Akt (1, 2, 3) activity in the solution phase.
UOM:
1 * 1 KIT
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Tumor necrosis factor alpha (TNF-α), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis.
Numéro de catalogue:
(ENZOADICSA824E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The TLRs (Toll-like receptors) are a group of evolutionarily conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine-rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADICOX030E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
COX-2 catalyze a cyclooxygenase (bis-oxygenase) reaction in which arachidonate plus two molecules of O2 are converted to PGG2 (prostaglandin G2), and a peroxidase reaction in which PGG2 undergoes a two-electron reduction to PGH2.
UOM:
1 * 1 EA
New Product
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