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ENZO LIFE SCIENCES
Fournisseur:
ENZO LIFE SCIENCES
Description:
Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.
Numéro de catalogue:
(ENZOALX804060C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Mouse, Isotype: IgG2a
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX802002R100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Mouse, Isotype: IgG1
UOM:
1 * 100 µl
New Product
Numéro de catalogue:
(ENZOALX803082C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX803081C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX803341C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 aa BIR (baculovirus inhibitor repeat) domain. Human members of the family include c-IAP1, c-IAP2, XIAP, survivin, livin and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression. In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7 and caspase-9. In addition, binding of IAP family members to the mitochondrial protein Smac blocks its interaction with caspase-9, thereby allowing the processing and activation of the caspase.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZPRT1790500)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in HEK 293 cells.
UOM:
1 * 500 µG
New Product
Numéro de catalogue:
(ENZOENZPRT1560010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in NSO cells.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZPRT1850025)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>.
UOM:
1 * 25 µG
New Product
Numéro de catalogue:
(ENZOENZPRT1900050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in HEK cells. Extracellular domain of PD-1 (aa 25-167) containing a 5’-His-tag, V5 epitope tag spacer, and a FLAG-tag.
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOALX400002G005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inhibitor of NF-κB activation (induced by either PMA or TNF-α) in various cell types.
UOM:
1 * 5 g
New Product
Numéro de catalogue:
(ENZOALX400004L050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Reagent for nitrite detection.
UOM:
1 * 50 mL
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Anti-inflammatory and antioxidant.
Numéro de catalogue:
(ENZOADI905746100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The actions of the octapeptide circulatory hormone angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane domain-containing GPCR family. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II in cardiovascular homeostasis. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905811100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven-transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1) receptors regulate vasoconstriction, and are expressed in vascular smooth muscle, kidney, myometrium, bladder, adipocytes, hepatocytes, platelets and testis; V1b (V3) receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus; and V2 receptors of the kidney regulate the antidiuretic effects of AVP. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOBMLCA11390100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Mouse, Isotype: IgG1
UOM:
1 * 100 µl
New Product
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