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ENZO LIFE SCIENCES
Numéro de catalogue:
(ENZOENZ52008)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Calcium dye
UOM:
1 * 1 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inhibitor of PP1 and PP2A
Numéro de catalogue:
(ENZOADICSA514E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADICSA509E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
SARM (SAM and ARM-containing protein) is thought to serve as an adaptor protein for the Toll-like receptors (TLRs) and allow for the activation of downstream kinases and NF-κB, ultimately leading to the expression of proteins involved in host defense.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI915062100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Metabolism of inositol phospholipids by intracellular signaling mediators is fundamental to signal transduction in eukaryotic cells. PI-4,5-P2 (Phosphatidylinositol 4,5-bisphosphate; PIP2) can be synthesized by phosphorylation of PI-4-P by type I phosphatidylinositol phosphate kinase (PIP5K I), or phosphorylation of PI-5-P by type II PIPK (PIP4K II). PI-4,5-P2 regulation of cellular calcium levels involves its hydrolysis by Phospholipase C (PLC) to produce inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), which serve as second messengers in the import of calcium via IP3-sensitive ion channels and in the activation of PKC, respectively.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI907028)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Hydrogen Peroxide Fluorometric Detection Kit provides fast results in just 10 minutes for the measurement of either hydrogen peroxide or peroxidase activity in a convenient one-step homogeneous assay.
UOM:
1 * 500 Tests
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Antioxidant and chemopreventive
Numéro de catalogue:
(ENZOBMLEI3360010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inhibits the translocation of Akt.
UOM:
1 * 10 mg
New Product
Numéro de catalogue:
(ENZOBMLEI3270025)
Fournisseur:
ENZO LIFE SCIENCES
Description:
URB-597 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide. Inhibition of FAAH may serve to enhance the analgesic effects of endogenous cannabinoids. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes and in intact neurons with IC50 values of 4.6nM and 0.5nM, respectively. The compound has also been shown to have anxiolytic effects in rats (ID50=0.15mg/kg). Because URB-597 acts on FAAH and does not interfere with the binding of anandamide to the CB1 and CB2 receptors, it is a novel tool for drug development.
UOM:
1 * 25 mg
New Product
Numéro de catalogue:
(ENZOBMLEI3350050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Tyrosine kinase inhibitor. It has been shown to block TNFα induced cytotoxicity and to block glucocorticoid-induced COX-2 activity in human amnion cells (IC50=21μM). It is also reported to inhibit guanylyl cyclase.
UOM:
1 * 50 mg
New Product
Numéro de catalogue:
(ENZOBMLEI3230001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cathepsin inhibitor
UOM:
1 * 1 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Tobramycine
Numéro de catalogue:
(ENZOALX520001C010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Potent immunomodulator. Mediates a wide range of immune and inflammatory responses including the activation of B and T cells.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Glucose-regulated protein 94 (Grp94, gp96), an abundant resident endoplasmic reticulum (ER) lumenal stress protein, belongs to the Hsp90 family of molecular chaperones along with cytosolic Hsp90. Grp94 and such other resident soluble proteins of the ER as the Ca 2+ binding protein subfamily (CaBP, CaBPI, CaBP2 and calreticulin) possess the C-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL), a sorting signal considered responsible for the retention of these proteins in the pre-Golgi compartments. Stress conditions such as glucose starvation and heat shock which promote protein misfolding or unfolding increase Grp94 expression. In addition to a homeostatic role in protein folding and assembly, Grp94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells. Grp94 and Hsp90 share high sequence identity and apparently identical adenosine nucleotide dependent modes of regulation, although previous data suggests that Hsp90 and Grp94 may differ in their nucleotide binding properties. The N-terminal domain of eukaryotic Hsp90 proteins contains a conserved adenosine nucleotide binding pocket which also serves as the binding site for the Hsp90 inhibitors geldanamycin and radicicol. However, the molecular basis for adenosine nucleotide-dependent regulation of Grp94 remains unclear. Data supports a ligand dependent regulation of Grp94 function, and suggests a model whereby Grp94 function is regulated through a ligand -dependent conversion of Grp94 from an inactive to an active conformation.
Numéro de catalogue:
(ENZOADI900004)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Highly sensitive ELISA, detecting as low as 1.40pg/ml in just 3 hours.
UOM:
1 * 1 KIT
New Product
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