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ENZO LIFE SCIENCES
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inhibitor of p53/MDM2 interaction
Fournisseur:
ENZO LIFE SCIENCES
Description:
Caspase-9 substrate
Numéro de catalogue:
(ENZOALX260088M001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Fluorogenic proteasome substrate.
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOALX260075M001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Caspase-6 inhibitor
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOBMLP2010500)
Fournisseur:
ENZO LIFE SCIENCES
Description:
CaM kinase inhibitor
UOM:
1 * 0,5 mg
New Product
Numéro de catalogue:
(ENZOBMLP2190500)
Fournisseur:
ENZO LIFE SCIENCES
Description:
PKC inhibitor
UOM:
1 * 0,5 mg
New Product
Numéro de catalogue:
(ENZOBMLP2280100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Sensitive fluorogenic substrate for TACE (TNFalpha converting enzyme, ADAM17). Also cleaved by ADAM10 and likely other ADAMs and MMPs. The kcat/Km of TACE for this substrate is 7-fold higher than for the same peptide with the Mca-Dpa fluorophore-quencher pair. FAM fluorescence is quenched by the TAMRA group until cleavage separates them. Ex.: 485 nm, Em.: 535 nm, although the following Ex/Em can also be used: 490,494/515,520 nm. This substrate is useful for inhibitor screening, kinetic analysis, and cellular activity assay.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOBMLP2130005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Substrate for neutrophil elastase and neutrophil proteinase 3
UOM:
1 * 5 mg
New Product
Numéro de catalogue:
(ENZOBMLP2420001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
This peptide, GGMEDIYFEFMGGKKK, identified by screening a degenerate peptide library, is a substrate for several kinases, including HER-2/c-neu/erb-B-2, Tie-2, cFMS, and cKit.
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOBMLP1910001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Akt substrate
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOBMLP2160001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
This peptide, EAIYAAPFAKKK, was identified as a high affinity (Km=4 µM) and specific substrate for the Abl kinase through a degenerate peptide library.
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOADI905778100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer, which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The N-terminal tail of core histones undergoes different post-transcriptional modifications including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905773100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified to date (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3β, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905803100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), provides the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/ nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905729100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR), an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus. Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR. ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone Grp78, but upon ER stress is released from Grp78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus. Nuclear ATF6, together with the transcription factor XBP-1, activates transcription of UPR-responsive genes.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX522110C010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
High-activity, high-purity CD40L construct for immune activation
UOM:
1 * 1 EA
New Product
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